# University of Michigan Center for Gastrointestinal Research

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $983,685

## Abstract

The ubiquitous distribution and actions of gut peptides on GI health and diseases catalyzed the formation of
the University of Michigan Gastrointestinal Peptide Research Center, which has been funded as a NIDDK P30
Research Core Center since 1984. These peptides now extend beyond their classical role as hormones to
include actions as paracrine effectors, neurotransmitters, growth factors and cytokines. Hence we changed the
name of our Center to the University of Michigan Center for Gastrointestinal Research to more accurately
reflect the comprehensive mission. The overreaching goal is to investigate signal transduction mechanisms
regulating homeostasis and GI disorders. Our approach will include studies on genetics and gene regulation,
cellular signaling pathways, receptors and ion channels. Our Research Base consists of 58 scientists and
clinical investigators with over $26 million in GI-related funding. The goals are to: (a) enhance rapid
translation of basic discoveries into clinical applications by providing a facilitative infrastructure to stimulate
interactions between basic scientists and clinical investigators; (b) promote interdisciplinary collaborative
projects to broaden the base of research that crosses traditional scientific boundaries; (c) offer specialized
technologies, equipment, reagents and expertise to assist Center members; (d) identify and nurture new GI
investigators via peer-reviewed pilot and feasibility program and career development workshops; (e) develop
scientific enrichment including visiting faculty programs, cross-disciplinary special topic seminars, new
technologies workshops and an annual Retreat where Center and guest Investigators may present their work.
The 3 major research themes reflecting the common research interests of numerous investigators affiliated
with the Center remain unchanged: 1) Neurobiology of visceral pain, enteric motility and appetite control, 2)
Molecular and Cellular Mechanisms of Inflammation, and 3) Cell Growth Differentiation and Programmed Cell
Death. In response to advances in new technologies and membership needs, we organized our Core labs into
(I) Molecular biology; (II) Protein localization, identification and folding; (III) Microbiome and metabolomics, and
(IV) In vivo animal and human studies. New changes include expanding Core I to include whole genome
sequencing and bioinformatics analysis, and genome-editing technology for molecular and animal studies.
Expanding Core II to include the characterization of protein folding and specialized proteomics, to facilitate
studies on protein misfolding that are important in the pathogenesis of pancreatitis, fatty liver and IBD. Core III
aimed at host-microbiome interactions and added a metabolomics arm to examine the functional pathways
regulating such interactions, and to study metabolome contributions to GI disease. Core IV expanded to
include an organoid service, biospecimen banking service and clinical design and statistics program to...

## Key facts

- **NIH application ID:** 10147040
- **Project number:** 5P30DK034933-35
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** JOHN W WILEY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $983,685
- **Award type:** 5
- **Project period:** 1996-12-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10147040

## Citation

> US National Institutes of Health, RePORTER application 10147040, University of Michigan Center for Gastrointestinal Research (5P30DK034933-35). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10147040. Licensed CC0.

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