# In Vivo Animal and Human Studies Core

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $170,425

## Abstract

The objective of the In Vivo Animal and Human Studies core is to provide a venue for focusing human 
resources, facilities, new technology and equipment necessary for the in vivo study of humans and animals. 
The core serves to fully integrate investigations at the molecular, cellular, and organ system levels that are 
currently being performed within other cores of the Center and enhance rapid translation of basic discoveries 
into clinical application. The major services provided by the In Vivo Animal and Human Studies core are as 
follows:1. To provide a variety of acute and chronic animal models as well as state-of-the-art in vivo 
technologies to enhance rapid translation of basic discoveries to physiological and clinical applications; 2. To 
develop an organoid and enteroid program in which these preparations grown from mucosa biopsies and 
induced pluripotent stem cells (iPSCs) may be used to study epithelial cell biology and provide therapeutic 
targets for clinical intervention; 3. To support a clinical study program which will provide consultation and 
technical support to Center investigators on design and statistical data analysis; and 4. To provide a user 
friendly, one-step service to access digestive disease-related biospecimens for Center members. Since its 
inception in 1984, the In Vivo Animal and Human Studies core has evolved to meet the needs of Center 
investigators. Over time, older techniques which are readily available in clinical facilities have been 
discontinued by the Center. We have streamlined our animal studies to include ones that are frequently 
utilized by Center investigators. These include mice endoscopy, in vivo cellular and molecular imaging studies 
in small animals, fluorescent-activated cell sorting (FACS) analysis, and electroporation for direct transfer of 
siRNA into targeted neuro-tissue or GI organs. The recent development of the Enteroid and Organoid core 
enables Center investigators to conduct research on in vitro models of human iPSCs, directed differentiation of 
human pluripotent stem cells (hPSCs), and 3-dimensional growth of primary human and mouse tissue 
delivered from the GI tract. These preparations may be used to study human GI development, homeostasis 
and disease in vitro. To enhance the rapid translation of basic science findings to clinical applications, the In 
Vivo Studies core has spent much of its efforts and resources to upgrade its infrastructure. The Clinical Design 
Program provides consultation regarding clinical study design, subject specification and sampling techniques, 
measurements and instruments, sample size estimation, power analysis, as well as data management and 
statistical analysis. The Biospecimen Banking service will provide support to enhance existing individual GI- 
related biobanks and develop future repositories. This service also centralizes, expedites, and facilitates 
access to GI-related biobanks and utilization of GI biospecimens to translate basic re...

## Key facts

- **NIH application ID:** 10147056
- **Project number:** 5P30DK034933-35
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** CHUNG OWYANG
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $170,425
- **Award type:** 5
- **Project period:** 2020-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10147056

## Citation

> US National Institutes of Health, RePORTER application 10147056, In Vivo Animal and Human Studies Core (5P30DK034933-35). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10147056. Licensed CC0.

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