# FASEB SRC on The Biology of Cilia and Flagella

> **NIH NIH R13** · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · 2021 · $16,000

## Abstract

Abstract
Cilia and flagella are thread-like cell organelles protruding from the cell surface into the
environment. Long neglected, research on the biology of cilia has seen tremendous growth over
the last two decades as their central role in cellular sensing and human disease emerged.
Defective cilia cause multi-organ disorders such as Bardet-Biedl, Meckel Gruber, and Joubert
syndrome. Cilia participate in several signaling pathways including vertebrate Hedgehog
signaling, which is critical for embryonic development and has been implicated in certain cancers
including basal cell carcinomas and medulloblastomas, the most common brain tumor in
juveniles. G-protein coupled receptors have key roles in mammalian sensing and signaling and
many of the receptors are located in cilia. Sensing of light and odors, for example, occurs in cilia
and cilia-based receptors have been implicated in the control of appetite, behavior and vision.
Thus, ciliary dysfunction contributes to common diseases such as blindness, diabetes and
obesity. The purpose of this proposal is to support the participation of junior scientists studying
cilia biology and cilia-related disease at the FASEB Summer Research Conferences on the
Biology of Cilia and Flagella in 2019, 2021 and 2023.
 The FASEB conference on cilia and flagella is the premier international meeting on cilia
signaling and cilia-related disease. The conference brings together cell, molecular, and
developmental biologists, human geneticists, biochemists, physician scientists and biophysicists
with interests ranging from the fundamental biology of cilia to the genetics and molecular
mechanisms of human cilia-based diseases and their treatment options. In this proposal, we
request funds to support junior scientists and investigators, who have not participated in this
FASEB conference before, to attend as speakers to promote growth and innovation of the field.
A Meet-the-Experts session will be held at the first day of the meeting to facilitate informal
interaction between senior members of the field meet and junior scientists and newcomers. We
will invite representatives from industry, foundations, teaching colleges and publishing to
participate in three workshops on career development and options in and outside of academia.
This international meeting is very well attended by postdocs and early stage investigators as well
as established experts in the field. This mix of attendees will further the goal of the conference of
generate research collaborations, identify key challenges in the field, and stimulate innovative
research on the biology of cilia, cilia-related disease and therapies.

## Key facts

- **NIH application ID:** 10147131
- **Project number:** 5R13HD098854-03
- **Recipient organization:** FEDERATION OF AMER SOC FOR EXPER BIOLOGY
- **Principal Investigator:** REBECCA D. BURDINE
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $16,000
- **Award type:** 5
- **Project period:** 2019-06-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10147131

## Citation

> US National Institutes of Health, RePORTER application 10147131, FASEB SRC on The Biology of Cilia and Flagella (5R13HD098854-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10147131. Licensed CC0.

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