# Clinical Core

> **NIH NIH P30** · MAYO CLINIC ROCHESTER · 2021 · $670,300

## Abstract

PROJECT DESCRIPTION/ABSTRACT – CLINICAL CORE
 The Clinical Core will serve as the focal point of the Mayo ADRC. The Clinical Core of the Mayo ADRC
has been among the leaders among Alzheimer's Disease Centers in recruiting and retaining participants. The
Mayo ADRC has focused and will continue to focus on imaging in the Alzheimer spectrum (AD), the genetics,
imaging and natural history of Frontotemporal Lobar Degeneration (FTLD) group of disorders and the imaging,
associated features (sleep, Parkinsonism, hallucinations, etc) and natural history of Lewy Body disorders
(LBD) spectrum (FTLD and LDB collectively the Alzheimer's disease related disorders “ADRD”). For each of
these etiologic entities, Mayo investigators hold NIH grants, in part due to the ADRC that utilize the ADRC
participant pool. Over the last cycle of funding, we have greatly expanded the number of participants,
including African Americans, who have undergone amyloid PET imaging. Moreover in the last grant cycle, we
introduced tau PET imaging as well in the MCR group, and we will do so soon in MCF. There are many
synergies that arise from our concurrent interest in AD and ADRD both for clinical characterization, but also for
biomarker evaluations, and basic science commonalities. The Clinical Core diagnostic and evaluative activities
will take place in both MCR and MCF, and the data derived from the evaluation schemes are entered into a
single database. The core procedures of the UDS3 are carried out according to NACC guidelines, and
additional evaluations specific to our programs are also conducted. All patients and controls undergo a
standardized series of interviews, examinations and biomarkers studies over 2-3 days. All participants are
seen by a neuropsychologist and neurologist. Our Specific Aims are to (1) Recruit, follow and supply to other
projects, patients with AD spectrum disorders; (2) Recruit, follow and supply to other projects patients, in the
ADRD spectrum; (3) Recruit African-Americans with above disorders (collaborating with ORE Core); (4)
Obtain DNA, blood, cerebrospinal fluid (collaborating with Biomarker Core) and multimodal imaging
(Collaborating with Neuroimaging Core) on participants; and (5) Obtain autopsies on Clinical Core participants
(collaborating with Neuropathology Core).

## Key facts

- **NIH application ID:** 10147622
- **Project number:** 5P30AG062677-03
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** DAVID S KNOPMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $670,300
- **Award type:** 5
- **Project period:** 2019-07-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10147622

## Citation

> US National Institutes of Health, RePORTER application 10147622, Clinical Core (5P30AG062677-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10147622. Licensed CC0.

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