# Method Development for Survival Dynamic Regression in Chronic Disease Research

> **NIH NIH R01** · EMORY UNIVERSITY · 2021 · $385,193

## Abstract

Project Summary
 In chronic diseases research, understanding and accounting for individual differences caused by genetic,
environmental, and lifestyle factors have become increasingly important for successful disease management.
Dynamic regression, as shown by recent work including ours, is a powerful technique to characterize and
identify inhomogeneous associations that explain individual variability of disease progression. The overall ob-
jective of this grant is to advance dynamic regression methodology to better meet the critical need of
uncovering disease mechanism heterogeneity with improved capacity to handle longitudinal/survival
outcomes and covariates in various complex forms (e.g. time-varying, high-dimensional, constrained).
 This application is motivated by our ongoing collaborations on Feeding Infants Right.. from the STart
(FIRST) study. Under the overreaching goal to identify optimal care for infants with Cystic Fibrosis (CF),
FIRST has systematically captured data on complete feeding history and longitudinally collected biomarkers
(e.g. blood lipids and fecal microbiota) and accessed nutritional status and pulmonary disease throughout
infancy. With the rich data collection, FIRST provides an unprecedented opportunity to exploit new sensible
quantifications of early CF phenotype (e.g. pulmonary, growth) and their dynamic associations with observed
factors (e.g. genotype, environmental factors); to assess breast/formula feeding schemes for CF infants; to fill
in the information gap on the influence of biomarkers on growth and their relationships to feeding.
 The specific aims of this grant are to develop innovative and effective dynamic regression tools that can help
achieve these impactful scientific goals: (1) We will investigate a sensible modeling perspective that focuses
on subject-level latent characteristics (called latent individual risk feature (LIRF) hereafter) as a substantive
reflection of disease risk/status (e.g. length growth rate ). We will develop formal dynamic regression methods
for delineating the heterogeneity in LIRF, which are not available in literature (Aim1). (2) We will develop
an innovative survival dynamic regression strategy that enables a comprehensive assessment of the overall
impact of time-dependent exposures (e.g. feeding history) on survival outcomes (e.g. time to pulmonary
exacerbation). Current methods usually describe the effects of time-dependent covariates progressively over
time and thus have limited utility for evaluating different feeding schemes (Aim2). (3) We will develop new
dynamic regression approaches that give an integrative account of important data challenges/features (e.g.
high-dimensionality, constraints, longitudinal outcomes, time-dependent covariates) for properly assessing
the mechanisms/roles of biomarkers during CF infancy (Aim3). (4) The proposed statistical methods will
be applied to FIRST and user-friendly software will be developed (Aims 4-5). Although specifically motivated...

## Key facts

- **NIH application ID:** 10147907
- **Project number:** 5R01HL113548-09
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Limin Peng
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $385,193
- **Award type:** 5
- **Project period:** 2012-08-06 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10147907

## Citation

> US National Institutes of Health, RePORTER application 10147907, Method Development for Survival Dynamic Regression in Chronic Disease Research (5R01HL113548-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10147907. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*