# 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB

> **NIH NIH U01** · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $101,697

## Abstract

Project Summary
This cooperative agreement (U01) application responds to NIH RFA–DA-15-015, Adolescent Brain Cognitive
Development (ABCD) study. The University of Hawaii (UH) is #2 of 9 Research Sites of the Prospective
Research in Studies of Maturation (PRISM) Consortium. The Consortium's objective is to establish a national,
multisite, longitudinal cohort to prospectively examine the neurodevelopmental and behavioral effects of
substance use (SU) from early adolescence through the period of risk for SU and SU disorders. This 10-year
longitudinal study of 11,000 children will measure brain development, SU, cognition, emotion, executive
function, mental health, physical health, environment, and collect biospecimens for future genetic and
epigenetic studies. The Consortium has an optimized research protocol and 4 specific aims: 1) Using
advanced multi-modal neuroimaging to evaluate premorbid factors and the impact associated with diverse
patterns of SU on structure and function of the developing brain. 2) Disentangle the predictors and
consequences of diverse patterns of SU on physical health, psychosocial and cognitive development,
academic achievement, motivation and emotional regulation. 3) Examine how the quantity and combination of
substances used affect the expression of psychopathology and, conversely, how the emergence of
psychopathology influences SU. 4) Assess how each substance used contributes to the use of other
substances (gateway interactions).
To further evaluate neurochemical and neurophysiological changes in these youth, we will additionally perform
1H MR spectroscopy (MRS), perfusion MRI (using arterial spin labeling or ASL), and quantitative susceptibility
mapping (QSM), in approximately half of our volunteers, in collaboration with PRISM sites at Penn, UCLA,
Utah, Hawaii, JHU, and Baylor.
We are proposing a multi-PI leadership approach for our site. The PIs have complementary and inter-
disciplinary expertise that encompasses all areas required to manage this comprehensive project. We have
expertise in SUD research, clinical assessments, subject sampling and recruitment, and MR methodology.
Additional unique qualifications of our site are: 1) we have access to a racially diverse population (including
Native Hawaiians and Pacific Islanders) that is disproportionately affected by SUD, 2) we have a strong track
record of MR research in SUD and at risk populations, such as adolescents, and 3) we have participated in
and led several multi-center research studies that involve complex multi-modal MR outcome measures and
subject assessments. Therefore, we have all the necessary resources, experience and expertise to conduct
the proposed research, and our effort will complement that of other outstanding research sites to collectively
achieve the overall goals of the PRISM Consortium.

## Key facts

- **NIH application ID:** 10148487
- **Project number:** 3U01DA041117-06S1
- **Recipient organization:** UNIVERSITY OF MARYLAND BALTIMORE
- **Principal Investigator:** LINDA CHANG
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $101,697
- **Award type:** 3
- **Project period:** 2015-09-30 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10148487

## Citation

> US National Institutes of Health, RePORTER application 10148487, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB (3U01DA041117-06S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10148487. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*