# Translational Imaging Shared Resource

> **NIH NIH P30** · ROSWELL PARK CANCER INSTITUTE CORP · 2021 · $83,381

## Abstract

The overall mission of the Translational Imaging Shared Resource (TISR) is to provide state-of-the-art
preclinical and translational imaging services to investigators at Roswell Park in a time-efficient and cost-
effective manner. The resource provides users access to advanced imaging modalities including magnetic
resonance imaging (MRI), ultrasound (US), photoacoustic imaging (PAI), fluorescence and bioluminescence
imaging (BLI). The resource is led by two PhD faculty with extensive experience in preclinical and clinical
imaging, and is the only shared resource within 200 miles of Buffalo that allows for multimodal anatomic and
functional imaging of small and large animal models of disease. TISR served a total of 67 Roswell users, of
which 60 (90%) were CCSG members, including 46 CCSG members with peer reviewed funding and 14
CCSG members without peer reviewed funding from all five research programs who are conducting basic and
translational investigations in oncology, radiology and cancer therapeutics. This has led to 4 patents and 71
peer-reviewed publications including several publications in top-tier cancer and imaging journals. In the past 5
years, TISR has provided imaging services for 41 NIH grants and 6 DoD grants. TISR was also awarded two
NIH S10 shared instrumentation grants that enabled expansion of its imaging services to include state-of-the-
art optical and optoacoustic imaging methods. The resource provides cancer center members 24/7 access to
and training in the application of non-invasive imaging technologies for their cancer research needs. The
specific aims of the TISR are to: 1) Provide Roswell Park investigators with access to state-of-the-art in vivo
imaging technologies; 2) Develop customized imaging protocols and quantitative image analysis schemes to
conduct preclinical trials of experimental therapeutics in small and large animal models of cancer; 3) Establish
a technology platform that facilitates clinical translation of imaging methods for improved disease detection and
therapy monitoring in patients. An integral part of TISR operations is the continual assessment of need for
expanding and/or updating imaging technology through evaluation of current demand, feedback from existing
users and anticipated future research needs of cancer center members. Future plans for TISR include
upgrading the existing MRI instrumentation and expansion of imaging services to include PET/SPECT and CT.

## Key facts

- **NIH application ID:** 10148660
- **Project number:** 5P30CA016056-44
- **Recipient organization:** ROSWELL PARK CANCER INSTITUTE CORP
- **Principal Investigator:** Mukund Seshadri
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $83,381
- **Award type:** 5
- **Project period:** 1997-06-16 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10148660

## Citation

> US National Institutes of Health, RePORTER application 10148660, Translational Imaging Shared Resource (5P30CA016056-44). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10148660. Licensed CC0.

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