# Population Sciences

> **NIH NIH P30** · ROSWELL PARK CANCER INSTITUTE CORP · 2021 · $45,965

## Abstract

The overall goal of the Population Sciences (PS) Program is to reduce and prevent morbidity and mortality
associated with cancer and its treatment, particularly cancer-related problems that are important to the
community that we serve. We strive to attain these goals through primary and secondary prevention, using
epidemiology and molecular approaches to identify risk factors for cancer and to make targeted efforts to
reduce exposure to these agents, particularly among populations who are most at risk. Because tobacco
smoke exposure is responsible for a large portion of the cancer burden, and use is high in our catchment area,
many of our efforts are targeted at reducing use of tobacco through a number of approaches. Our research
also focuses on tertiary prevention, to understand factors that may impact treatment outcomes, and to design
interventions to improve prognosis. To address these goals for primary, secondary and tertiary prevention, our
research is driven by three specific aims. 1) To reduce the burden of smoking-related cancers by preventing
exposure to tobacco and tobacco products, with research focused at the individual, regional, national and
global levels; 2) using molecular epidemiology, to understand who is at high risk of cancer from exposures and
susceptibility, and to elucidate underlying biologic pathways of carcinogenesis, to inform prevention and early
detection strategies; and 3) to investigate factors that influence cancer treatment outcomes, to enhance quality
of life and improve survival.
 The PS program is co-led by Drs. Christine Ambrosone and Andrew Hyland, who have complementary
expertise that bridges these aims. Together, they facilitate research in discovery, to identify genetic and
environmental causes of cancer and its outcomes as well as approaches to prevention, reducing exposure to
etiologic factors and devising interventions to reduce risk and improve cancer survival. In addition to a large
portfolio of research in molecular epidemiology, disparities and tobacco control, highlights in the last funding
period included P01-and R01-funded intra- and inter-programmatic research on the etiology of aggressive
breast cancer in African-American women, with findings leading to interventions in the community led by
members of the Community Outreach and Engagement Office, and leadership of the largest longitudinal study
of tobacco use and health outcomes ever conducted, the Path Study, including more than 45,000 participants,
which will inform FDA regulatory science. The 25 members of the PS Program have $4.1M in total peer
reviewed funding, of which $2.9M is from NCI. Of the 521 publications since 2013, 47 (9%) were published in
journals with impact factor > 10, with 113 (22%) inter programmatic, 112 (21%) intra programmatic, and 487
(93%) collaborative with investigators at other institutions. In the coming cycle, PS members will continue to
build upon their strengths, and to expand into areas where there are current ...

## Key facts

- **NIH application ID:** 10148664
- **Project number:** 5P30CA016056-44
- **Recipient organization:** ROSWELL PARK CANCER INSTITUTE CORP
- **Principal Investigator:** Christine B. Ambrosone
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $45,965
- **Award type:** 5
- **Project period:** 1997-06-16 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10148664

## Citation

> US National Institutes of Health, RePORTER application 10148664, Population Sciences (5P30CA016056-44). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10148664. Licensed CC0.

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