# Sex related differences in the effect of cognitive behavioral therapy on emotional arousal and salience circuits and the role of the gut microbiome

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $256,623

## Abstract

ABSTRACT
Cognitive Behavioral Therapy (CBT) is the most well researched and most effective treatment for IBS that
targets the brain-gut-microbiome (BGM) axis, and preliminary data show that this therapeutic effect is
associated with a reduction of brainstem connectivity with other brain networks and a change in relative
abundance of Bacteroides taxa. The increased prevalence of IBS in women, the higher rate of comorbid non-
GI pain conditions, as well as the higher prevalence in female IBS of increased sensitivity to a variety of
internal and external stimuli (multisensory sensitivity) suggest the presence of important sex differences in
some of these BGM mechanisms. Research performed by the UCLA SCOR during previous funding has
established an increased responsiveness of the CRF-Locus Coeruleus system in female IBS subjects,
suggesting that this noradrenergic brainstem system plays an important role in IBS pathophysiology. In
addition, our earlier research has begun to identify clinical, functional and cortical brain mechanisms that may
underlie these sex effects. Based on these preliminary data, the overall goal of this Project is to use CBT as a
probe to study the relationship between specific disease-related alterations of the brain, brainstem, the gut
microbiome, and symptomatic outcome, and identify the role of sex differences in these relationships. We will
study male and female IBS patients before and after CBT or usual care using the advanced neuroimaging and
microbiome technologies of the overall SCOR to test the following: Aim A. will identify sex differences in the
impact of CBT on the connectivity between brainstem nuclei and brain networks and between these networks
at rest and after provocation. Aim B. will identify sex differences in the impact of CBT on gut microbiome
parameters and Aim C will identify clinical, brain and gut microbiome predictors of CBT outcomes.

## Key facts

- **NIH application ID:** 10149315
- **Project number:** 5U54DK123755-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Emeran A Mayer
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $256,623
- **Award type:** 5
- **Project period:** 2020-05-01 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10149315

## Citation

> US National Institutes of Health, RePORTER application 10149315, Sex related differences in the effect of cognitive behavioral therapy on emotional arousal and salience circuits and the role of the gut microbiome (5U54DK123755-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10149315. Licensed CC0.

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