# Paracrine Modulation of Cardiac Repair processes by Cortical Bone Derived Stem Cells

> **NIH NIH R01** · TEMPLE UNIV OF THE COMMONWEALTH · 2021 · $396,250

## Abstract

Project summary
Ischemic heart disease (IHD) is a major cause of morbidity and mortality in the US. Cell-based
therapies have recently emerged as a promising alternative to existing pharmacological and
surgical procedures for augmentation of cardiac structure and function. Success of animal
studies and preclinical models of cell therapy have provided the basis for clinical testing of
different stem cell types in heart failure patients. Although, stem cell administration has largely
resulted in better prognosis in patients yet functional gains remain incremental. The adoptively
transferred stem cells are hampered in their ability to survive, engraft and proliferate in the
ischemic myocardium environment. Moreover, a critical need is felt to understand interaction of
the transplanted stem cells with the ischemic cardiac environment. The injured myocardium
secretes factors that recruit and mobilize immune cells to the site of injury involved in removing
dead tissue and scar formation as part of the cardiac inflammatory/immune response.
Transplanted stem cells are exposed to pro-inflammatory factors and activated immune cells but
their effect remains unknown. The fundamental question is whether cardiac
inflammatory/immune response is a determinant of stem cell mediated cardiac repair. We have
recently identified cortical bone derived stem cells (CBSCs) from the bone stroma and their
administration in the heart enhances function after myocardial damage. Our preliminary findings
show that CBSCs possess properties of survival and proliferation compared to other known
stem cell types. Importantly, CBSCs salutary effects are tied to secretion of paracrine factors
that modulate cardiac immune response after injury. Therefore, we hypothesize that CBSCs
paracrine factors transform cardiac immune cells into a pro-reparative state enhancing their
contribution towards myocardial repair response after injury. Our goal is to understand the
interaction of transplanted CBSCs and cardiac immune response and determine its
consequence for repair in the heart following injury. We will extend these studies to develop a
therapeutic strategy for delivery of CBSCs paracrine factors to promote cardiac repair response
after myocardial damage. CBSCs paracrine modulators represent a new direction to enhance
cardiac structure and function in after ischemic injury.

## Key facts

- **NIH application ID:** 10149385
- **Project number:** 5R01HL137850-04
- **Recipient organization:** TEMPLE UNIV OF THE COMMONWEALTH
- **Principal Investigator:** Sadia Mohsin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $396,250
- **Award type:** 5
- **Project period:** 2018-09-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10149385

## Citation

> US National Institutes of Health, RePORTER application 10149385, Paracrine Modulation of Cardiac Repair processes by Cortical Bone Derived Stem Cells (5R01HL137850-04). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10149385. Licensed CC0.

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