# Vermont Immunobiology / Infectious Diseases Center

> **NIH NIH P30** · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2020 · $312,000

## Abstract

PROJECT SUMMARY/ABSTRACT
 Influenza virus epidemics cause significant morbidity and mortality each year. Host determinants of infection
severity and pathogenesis remain poorly defined. Sex differences in influenza infection outcomes are well
documented, but not well understood mechanistically. Our previous funding from NIAID and VCIID COBRE has
enabled us to conduct a genome wide screen of host genetic determinants of influenza virus pathogenesis, using
a unique genetic model of natural genetic variation in mice. Our screen has identified two loci, one on
chromosome 5 and the other on chromosome X, that significantly modify sex differences in influenza
pathogenesis. We propose to begin a dissection of the mechanisms underlying these genetically regulated sex
differences. Additionally, we will extend these studies to include young pre-pubertal mice.

## Key facts

- **NIH application ID:** 10149599
- **Project number:** 3P30GM118228-05S2
- **Recipient organization:** UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
- **Principal Investigator:** Ralph C Budd
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $312,000
- **Award type:** 3
- **Project period:** 2016-08-05 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10149599

## Citation

> US National Institutes of Health, RePORTER application 10149599, Vermont Immunobiology / Infectious Diseases Center (3P30GM118228-05S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10149599. Licensed CC0.

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