# Neuropathology Core

> **NIH NIH P30** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $272,129

## Abstract

Mount Sinai ADRC (Sano): Neuropathology Core (Core D) – Research Summary
The overarching aim of the Neuropathology core is to promote research in AD by providing exceptionally well
characterized postmortem human brain tissue and related specimens to ADRC and non-ADRC researchers
within and outside the Mount Sinai neuroscience community and to support the ADRC cores, including the
Clinical, Biomarker, Genetics, Education and Data Management cores. The Core's enduring goal and practice
of providing accurate assessments and well-characterized brain tissues and derivatives to the neuroscience
community is precisely aligned with the National Plan to Address Alzheimer's Disease. Emerging and potentially
paradigm-shifting neuropathological concepts, such as AD subtypes, depend on the availability of well-
characterized brains from extensively phenotyped donors for research. Yet, there is an alarming shortage of well
annotated specimens and neuropathologists with expertise to support the research community. The overall aim
of this core is to continue to maintain and operate the Brain Bank in such a way as to meet the dementia research
needs of neuroscience laboratories optimally while providing state-of the art neuropathologic characterization of
all brain specimens referred to the bank by the clinical core. In addition, Core D endeavors to anticipate the
research needs of the future by banking multiple non-CNS specimens to enable: a) the translation of findings in
the CNS to readily accessible biomarkers; and b) studies of systemic and environmental influences on dementia
neuropathology. The specific aims of the Brain Bank/Neuropathology Core are to: maintain, manage and expand
a large dementia brain biorepository; enable and facilitate state-of-the-art translational research; determine and
record quantitatively the extent and distribution of relevant lesions present within each brain specimen; provide
training opportunities for new core leaders and neuropathology researchers.

## Key facts

- **NIH application ID:** 10149905
- **Project number:** 5P30AG066514-02
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** VAHRAM HAROUTUNIAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $272,129
- **Award type:** 5
- **Project period:** 2020-05-01 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10149905

## Citation

> US National Institutes of Health, RePORTER application 10149905, Neuropathology Core (5P30AG066514-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10149905. Licensed CC0.

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