# Controlled Exposure Informatics/Modeling Facility Core

> **NIH NIH P30** · RBHS-SCHOOL OF PUBLIC HEALTH · 2021 · $180,335

## Abstract

ABSTRACT: CONTROLLED EXPOSURE AND INFORMATICS/MODELING FACILITY CORE 
Precision Environmental Health (PEH) research is anchored in elucidating how exposure leads to adverse 
outcomes. The CEIM Core has two Units to support PEH research, one that provides facilities and expertise 
for controlled exposures experiments and a second for informatics and systems computational modeling of 
exposures and effects. The Controlled Exposure (CE) Unit provides platforms for exposing healthy and 
diseased individuals and animals to specific, controlled conditions for biomarker discovery and validation. The 
Informatics/Modeling (I/M) Unit provides computational tools for large-scale environmental and biological data 
analytics as well as mechanistic-systems modeling of environmental and biological processes and interactions. 
The Core thus provides powerful tools for building and implementing a crucial component of PEH research. 
The CE Unit provides CEED investigators with the capability of collecting real-time exposure data from human 
subjects and experimental animals in a controlled setting using defined atmospheres that mimic environmental 
or occupational exposures, while limiting confounders. The CE Unit supports studies on interactions between 
chemical exposures and variables such as temperature, humidity, exercise, psychosocial stress, and pre- 
existing disease (e.g., asthma). Physiological and behavioral responses of humans and rodents can be 
measured simultaneously to the exposure administered in either the human Controlled Exposure Facility or the 
Animal Exposure Facility. State-of-the-art pollutant generation and monitoring systems are used for both. The 
I/M Unit provides informatics expertise and computational support for the integrative analysis of large 
heterogeneous data sets from multiple sources, using emerging science, engineering, and technology. These 
data sets include health outcomes and exposure-relevant information from both public and proprietary sources. 
The I/M Unit provides resources to address the many challenges presented by the volume of data that are 
rapidly becoming available from “new sources” being used in exposure science and the biomedical fields. It 
also supports CEED investigators’ need to model mechanisms involved in the “source to dose to exposure to 
effect” process. The I/M Unit fills these needs by providing access to high-level data integration and analytics 
and systems modeling tools that can be used to estimate exposure and dose, and identify or predict early 
biological responses, for the purpose of designing intervention and prevention strategies that modify risk of 
disease. The Unit is integral to CEED’s focus on populations and communities, as it can inform decisions 
about alternative prevention and remediation strategies that arise from our community-researcher partnerships. 
Additionally, the I/M Unit provides support to CoEC through computational tools (e.g. interactive visualization 
and mapp...

## Key facts

- **NIH application ID:** 10150003
- **Project number:** 5P30ES005022-34
- **Recipient organization:** RBHS-SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** PANOS G. GEORGOPOULOS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $180,335
- **Award type:** 5
- **Project period:** 1997-04-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150003

## Citation

> US National Institutes of Health, RePORTER application 10150003, Controlled Exposure Informatics/Modeling Facility Core (5P30ES005022-34). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10150003. Licensed CC0.

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