# Core B: Biochemistry and Pathology

> **NIH NIH P01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2021 · $305,120

## Abstract

CORE B: Summary
Accumulation of inflammatory macrophages is a common feature in the atherosclerotic plaque and the visceral
adipose tissue during obesity1, 2. In diabetes, this pathogenic process hinders the regression of atherosclerosis,
and in obesity, it promotes insulin resistance and metabolic dysfunction. The ability to examine plaque and
adipose tissue macrophages, and associated changes in gene expression and biochemistry within these
macrophage populations during diabetes and diet-induced obesity and insulin resistance are important
features of this Program Project. As such, a Core will be established to: (1) Isolate and quantify macrophage
subsets, and other immune cell subsets from atherosclerotic plaque and adipose tissue by FACS, and (2)
monitor changes in gene expression and metabolic parameters within atherosclerotic plaque and adipose
tissue macrophages. These procedures are key to the successful execution of the Aims throughout this
Program Project, and centralizing the gene expression analyses, immunohistochemical and biochemical
assays will ensure consistency and reproducibility, which in turn will maximize the efficiency and productivity of
the scientists within each project.

## Key facts

- **NIH application ID:** 10150064
- **Project number:** 5P01HL131481-05
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** KATHRYN J MOORE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $305,120
- **Award type:** 5
- **Project period:** 2017-05-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150064

## Citation

> US National Institutes of Health, RePORTER application 10150064, Core B: Biochemistry and Pathology (5P01HL131481-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10150064. Licensed CC0.

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