# The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement Core

> **NIH NIH U54** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $488,705

## Abstract

PROJECT SUMMARY/ABSTRACT – PUBLIC ENGAGEMENT CORE - EPIBIOS4RX
The overarching goal of the Public Engagement Core is to actively engage voluntary organizations
with the EpiBioS4Rx CWOW in public outreach and knowledge transfer for the development of
effective strategies to successfully design and complete clinical research studies, including future
trials of prevention therapy in epilepsy. The scientific premise of EpiBioS4Rx is: Epileptogenesis after
traumatic brain injury (TBI) can be prevented with specific treatments; the identification of relevant biomarkers
and performance of rigorous preclinical trials will permit the future design and performance of economically
feasible full-scale clinical trials of antiepileptogenic therapies.
The Public Engagement Core aims at creating a consortium of consumers and consumer organizations,
scientific (professional) societies, health organizations and EpiBioS4Rx investigators to assist with public
outreach and facilitate interactions and communication among our partners to effectively promote participatory
action research. To achieve a solid grounding between concept, practice and action, we have recruited several
constituencies in the planning and decision making processes. A unique feature of our proposed patient
engagement program is the preventative nature of this study. We are planning to involve patients who have
suffered TBI and are considered to be at risk of developing epilepsy, but do not currently have the condition.
Therefore, we are seeking patient involvement in the development of recruitment strategies for clinical trials for
epileptogenesis, to which the patients may or may not develop. Subsequently, the Public Engagement Core
will involve both consumers (actual patients and their caregivers) and consumer groups in identifying effective
strategies to design large-scale interventional clinical trials of antiepileptogenic therapies in TBI and committed
to effective recruitment and retention.
The ultimate objective of the Core is to create a universal shared resource for epilepsy involving consumers
and consumer organizations that could be used to design and execute large-scale intervention studies.

## Key facts

- **NIH application ID:** 10150104
- **Project number:** 5U54NS100064-05
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** SOLOMON L. MOSHE
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $488,705
- **Award type:** 5
- **Project period:** 2017-01-15 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150104

## Citation

> US National Institutes of Health, RePORTER application 10150104, The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement Core (5U54NS100064-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10150104. Licensed CC0.

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