# Core D:  Clinical Recruitment

> **NIH NIH U19** · YALE UNIVERSITY · 2020 · $695,543

## Abstract

Abstract
In depth immunoprofiling of COVID-19 patients will be established to identify critical elements of
the immune responses to the corona virus SARS-Co-V-2. This study is part of the IMPACC
study group formed to conduct in depth analyses of samples from COVID-19 patients. Shared
protocols for subject enrollment and sample collection have been established by the IMPACC
study group to be collected across key time points of the disease. Our analysis will include
broad phenotyping of cell subsets and transcriptional responses of critical patient samples.
Results will be assessed with the IMPACC study group bioinformatics team for integration with
results from IMPACC core facilities on the same samples such as bulk RNASeq, serum
proteomics and metabolomics, DNA sequencing, and multiparameter single cell CyTOF of
endotracheal aspirates. Our studies to clarify and elucidate critical pathways in COVID-19
pathogenesis and immune response will guide development of anti-viral therapeutics and
vaccines to maximize resistance to the virus.

## Key facts

- **NIH application ID:** 10150157
- **Project number:** 3U19AI089992-09S3
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Albert C Shaw
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $695,543
- **Award type:** 3
- **Project period:** 2020-05-18 → 2021-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150157

## Citation

> US National Institutes of Health, RePORTER application 10150157, Core D:  Clinical Recruitment (3U19AI089992-09S3). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10150157. Licensed CC0.

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