# Asthma and Allergic Diseases Group

> **NIH NIH UM2** · RHO FEDERAL SYSTEMS DIVISION, INC. · 2020 · $10,601,507

## Abstract

PROJECT SUMMARY / ABSTRACT
 COVID-19, the infectious disease caused by SARS-CoV-2, is rapidly affecting humans around the globe.
While initial epidemiological data have focused on cases that resulted in severe respiratory disease seen
predominantly in adults, little information regarding the infection burden in children is available. This is
complicated by the observation that many virologically confirmed cases in children are asymptomatic (Dong et
al, Pediatrics, PMID 32179660). Undocumented, and likely infectious, cases could result in exposure to a far
greater proportion of the community than would otherwise occur. Indeed, it has been proposed that
undocumented (or silent) infections are the source for almost 80% of documented infections (Li et al, Science,
PMID 32179701); thus, it is critical to determine the silent and symptomatic infection rate in children.
 The purpose of this project is to develop, implement, and report on a surveillance study that will enroll and
prospectively observe eligible children who are current participants in NIH/NIAID/DAIT-funded pediatric
research studies and their family members. Many of these studies are focused on populations of children with
asthma or other atopic conditions. The primary objective of this study will be to determine the incidence of
SARS-CoV-2 infection (detection of virus in nasal secretions and stool and antibodies to the virus in blood)
over time in children and their household contacts (caregivers and siblings).

## Key facts

- **NIH application ID:** 10150761
- **Project number:** 3UM2AI117870-06S1
- **Recipient organization:** RHO FEDERAL SYSTEMS DIVISION, INC.
- **Principal Investigator:** Samuel Arbes
- **Activity code:** UM2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $10,601,507
- **Award type:** 3
- **Project period:** 2020-05-08 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150761

## Citation

> US National Institutes of Health, RePORTER application 10150761, Asthma and Allergic Diseases Group (3UM2AI117870-06S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10150761. Licensed CC0.

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