# Shared Resource - Histopathology & Tissue Shared Resource

> **NIH NIH P30** · GEORGETOWN UNIVERSITY · 2021 · $116,163

## Abstract

ABSTRACT 
The Histopathology & Tissue Shared Resource (HTSR) is the Georgetown Lombardi Comprehensive Cancer 
Center (LCCC) resource for accessing human tissue for translational research and provides comprehensive, 
high-quality laboratory and interpretive pathology services. The HTSR collects and distributes fresh, frozen and 
formalin-fixed, paraffin-embedded tissues (10,773 patients consented to date) and supplies technical and 
pathology support for investigator-driven collection protocols, including the novel conditionally reprogrammed 
cells (CRCs) and zevatar projects. HTSR Codirector Brent Harris, MD, PhD, oversees the delivery of HTSR’s 
comprehensive pathology services related to human and animal tissues. Under the day-to-day management of 
Codirector Deborah Berry, PhD, the laboratory provides human tissue and liquid biospecimens for translational 
research projects and comprehensive histology services, including tissue processing, paraffin and frozen section 
microtomy, staining, immunohistochemistry (IHC), immunofluorescence, laser-capture microdissection and 
tissue microarray (TMA) construction, staining and interpretative analysis. The HTSR also offers expert 
bioinformatics technical support, pathology database search capabilities, consultation services and educational 
support and training for users. In response to user surveys, investigator feedback and Advisory Committee 
recommendations since the last review, the HTSR has expanded its services to include quantitative automated 
brightfield and immunofluorescence image analysis, immunophenotyping, microRNA (miRNA) in situ staining 
and TMA construction. The HTSR works cooperatively with the Genomics & Epigenomics Shared Resource 
(GESR) and the Proteomics & Metabolomics Shared Resource (PMSR) to prepare human and animal model 
tissues for downstream genomic, proteomic and metabolomic analysis. The HTSR works cooperatively with the 
Biostatistics & Bioinformatics Shared Resource (BBSR) to document clinical information and patient outcomes 
comprehensively for samples distributed from the HTSR, including specimens collected by the Survey, 
Recruitment & Biospecimen Collection Shared Resource (SRBSR) and Indivumed GmbH. Forty peer review– 
funded LCCC investigators representing all four LCCC Research Programs (Breast Cancer [BC], Cancer 
Prevention and Control [CPC], Experimental Therapeutics [ET], and Molecular Oncology [MO]) used the HTSR 
in 2017. The impact of the HTSR is demonstrated by the 70 peer-reviewed publications that have used HTSR 
resources in the current funding period.

## Key facts

- **NIH application ID:** 10150778
- **Project number:** 5P30CA051008-28
- **Recipient organization:** GEORGETOWN UNIVERSITY
- **Principal Investigator:** BRENT T HARRIS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $116,163
- **Award type:** 5
- **Project period:** 1997-08-15 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150778

## Citation

> US National Institutes of Health, RePORTER application 10150778, Shared Resource - Histopathology & Tissue Shared Resource (5P30CA051008-28). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10150778. Licensed CC0.

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