# NDEx - the Network Data Exchange A Network Commons for Biologists

> **NIH NIH U24** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $739,682

## Abstract

Summary
Knowledge of the hallmark networks of cancer has been key to interpreting the molecular heterogeneity
seen within and across tumors. NDEx, the Network Data Exchange (www.ndexbio.org), is an online
commons where scientists can upload, share, and publicly distribute molecular networks and pathway
models. We are currently two years into a three-year grant from the National Cancer Institute (U24
CA184427A), during which time we have created the NDEx open-source platform; released NDEx as
a public website; and begun to link NDEx to applications such as Cytoscape. Having built this initial
system, our goals for the next funding period are to rapidly develop NDEx network content and
communities and the means by which these resources impact cancer research and treatment. In
particular, we will (1) Connect NDEx networks to next-generation cancer genome analysis; (2)
Enable the direct publishing of interactive networks on journal websites; (3) Develop hallmark
cancer pathway content via social organization and automation; and (4) Scale the NDEx
framework to support a growing community of users and analysis tools. Through these aims, the
emphasis of the NDEx Project transitions from core infrastructure to genome analysis workflows,
cancer-relevant network content, publishing, and community building. These developments address a
strong and immediate need in cancer research for a cyberinfrastructure that can analyze genome-scale
information in the context of molecular networks.

## Key facts

- **NIH application ID:** 10150829
- **Project number:** 5U24CA184427-08
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Dexter Pratt
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $739,682
- **Award type:** 5
- **Project period:** 2014-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150829

## Citation

> US National Institutes of Health, RePORTER application 10150829, NDEx - the Network Data Exchange A Network Commons for Biologists (5U24CA184427-08). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10150829. Licensed CC0.

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