# Administrative Core

> **NIH NIH P01** · SCRIPPS FLORIDA · 2021 · $133,018

## Abstract

PROJECT SUMMARY/ABSTRACT 
 The overall theme of this program project grant is to study the pathophysiology of genetically defined 
dementia and neurodegeneration to: (i) define therapeutic targets and pathways; (ii) develop small molecule 
chemical probes to study various modes of toxicity; (iii) develop biomarkers as diagnostics for c9FTD/ALS; and 
(iv) study the chemical probes in vivo to advance development of pre-clinical candidates. The proposal builds 
on the significant discoveries made by investigators in this program project and on past collaborations among 
all of the investigators involved in the P01. The Administrative Core (Core A) is charged with ensuring the 
success of this research proposal. Core A will have several functions to assure the success of this research 
proposal. As Core A Leader and Program Project Director, Matthew Disney, Ph.D., is uniquely positioned 
to leverage available resources to foster a multidisciplinary program project that advances research, generates 
valuable biological and chemical resources and promotes education on this class of devastating neurological 
disorders. Core A will have access to administrative assistance with grants administration and all aspects of 
human subject research. The Aims are: 
 Aim 1. Provide administrative structure and fiscal oversight for the program project grant. 
 Aim 2. Organize regular meetings of the Executive Committee composed of Project and Core 
Leaders and other key personnel to assist in scientific administration and to facilitate integration and 
continuing progress on research aims. 
 Aim 3. Establish an external Executive Advisory Committee, conduct annual meetings, and report 
progress to the NINDS. 
 Aim 4. Report progress to NIH and ensure compliance with the NIH Public Access policy. 
 Aim 5. Enable the program project to transition to the NIH's The Blueprint Neurotherapeutics 
Network. The overall goal of our collective proposed work is to advance therapeutics and biomarkers to the 
clinic to treat those afflicted with c9FTD/ALS. 
 Aim 6. Promote education on FTD, ALS and related disorders, and encourage P01 scientists and 
clinicians to participate in patient and caregiver support groups. Core A will leverage its allocated 
resources to promote education on FTD, ALS and related disorders at all three institutions, including invited 
speaker seminar series and various events hosted for the public.

## Key facts

- **NIH application ID:** 10150903
- **Project number:** 5P01NS099114-05
- **Recipient organization:** SCRIPPS FLORIDA
- **Principal Investigator:** Matthew D Disney
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $133,018
- **Award type:** 5
- **Project period:** 2017-06-15 → 2022-04-01

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150903

## Citation

> US National Institutes of Health, RePORTER application 10150903, Administrative Core (5P01NS099114-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10150903. Licensed CC0.

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