# Research Supplement to Promote Diversity in Health-Related Research

> **NIH NIH R01** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2020 · $63,039

## Abstract

SUMMARY
The main goal of this research training plan for Mr. Alhaji Janneh’s academic and scientific development is to
define the downstream mechanism by which alterations in sphingolipid metabolism and signaling regulates
tumor metastasis via cross talk between TßRI/II and S1P signaling in solid tumors. This research goal is
related to the expansion of studies proposed in the Specific Aim 3 of the parent grant. This proposal is
designed to test the novel hypothesis that increased metabolism/hydrolysis of CerS4/ceramide to generate
S1P induces cancer cell migration and tumor metastasis by crosstalk between TßRI and S1PR1 receptors via
activation of complement signaling. In addition to robust and rigourous research training plan, there is a strong
mentoring plan that is in line with Mr. Alhaji Janneh’s future career plans in a strong scientific and academic
environment in PI’s laboratory. This supplemental application will provide increased diversity and development
of a minority researcher as an independent academic faculty in cancer research.

## Key facts

- **NIH application ID:** 10150946
- **Project number:** 3R01CA214461-03S1
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Besim Ogretmen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $63,039
- **Award type:** 3
- **Project period:** 2018-08-31 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10150946

## Citation

> US National Institutes of Health, RePORTER application 10150946, Research Supplement to Promote Diversity in Health-Related Research (3R01CA214461-03S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10150946. Licensed CC0.

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