# Sample Processing and Analysis

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2021 · $282,433

## Abstract

ABSTRACT
This core's mission is to facilitate translational and laboratory-based research performed by all program
investigators. The core supports 4 functions: 1) processing and cryopreservation of primary AML and MDS
samples; 2) annotation of primary samples with pathologic, cytogenetic and flow cytometry data; 3) annotation
of primary AML samples with genomic and functional data; and 4) maintain a bank of AML cell lines, primagrafts
and in vitro models suitable for functional assays. As of November 2018, 12,790 bone marrow samples have
been banked from 3,590 unique patients with hematologic malignancies. All of these samples were obtained
from patients enrolled on IRB-approved sample collection protocol DF/HCC 01-206: Blood and Bone Marrow
Sample Collection for Research Studies in Patients with Hematologic Malignancies, Bone Marrow Disorders,
and Normal Donors. The bank includes samples from 1473 patients with AML and 634 patients with MDS. The
samples have been extensively used to support clinical and laboratory research over the last five years in support
of drug development, analysis of oncogene function and prognosis, development of BH3 profiling, creation of a
large bank of genomically defined PDX models of AML, and other laboratory studies.

## Key facts

- **NIH application ID:** 10152558
- **Project number:** 5P01CA066996-22
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** JAMES DOUGLAS GRIFFIN
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $282,433
- **Award type:** 5
- **Project period:** 1997-04-25 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10152558

## Citation

> US National Institutes of Health, RePORTER application 10152558, Sample Processing and Analysis (5P01CA066996-22). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10152558. Licensed CC0.

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