# Translational Control: Discovery and Mechanisms

> **NIH NIH R35** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2021 · $563,805

## Abstract

Project Summary/Abstract
Ribosomes are at the center of gene expression regulation. Not only do they synthesize
proteins, but they regulate transcription and respond to stress signals. The translational control
underlies the pathogenesis of infectious and genetic diseases. Translation is a key antibiotic
target, but the emergence of antibiotic resistance poses a serious challenge in the fight against
infectious diseases. To improve our understanding of the translational control of gene
expression in molecular detail, we propose to elucidate the structural mechanisms of (1)
translation initiation of viral mRNAs and virus-like cellular mRNAs; (2) bacterial stress responses
which couple translation with transcription, conferring bacterial pathogenicity and antibiotic
resistance and (3) translation elongation and termination. Understanding these mechanisms
may enable discovery of novel drugs for the treatment of viral or bacterial infections or genetic
diseases caused by nonsense mutations.

## Key facts

- **NIH application ID:** 10152613
- **Project number:** 5R35GM127094-04
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Andrei Korostelev
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $563,805
- **Award type:** 5
- **Project period:** 2018-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10152613

## Citation

> US National Institutes of Health, RePORTER application 10152613, Translational Control: Discovery and Mechanisms (5R35GM127094-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10152613. Licensed CC0.

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