# Phenotypic and repertoire analysis of protective CD4 T cells induced by prime-boost vaccination against Chlamydia

> **NIH NIH P20** · UNIV OF ARKANSAS FOR MED SCIS · 2020 · $303,099

## Abstract

PROJECT SUMMARY/ABSTRACT
 Addressing infectious disease in a therapeutically relevant fashion requires an understanding of both the
microbial virulence factors that contribute to the disease process and the manner in which these factors impact
the host immunological and inflammatory response. Achieving this will provide an opportunity to develop novel
strategies to influence the pathogen and/or host response in favor of the host, thereby providing a perfect
opportunity for clinically relevant translational research. Thus, achieving this understanding continues to be the
overall goal of our Center for Microbial Pathogenesis and Host Inflammatory Responses. The key element to
accomplishing this is to assemble a critical mass of investigators, each under the mentorship of established
senior faculty, whose research is consistent with this underlying scientific theme and the overall goals of our
Center. The underlying hypothesis that ties these investigators together is that targeting diverse microbial
pathogens in the context of their impact on immunological and inflammatory responses in their common human
host will optimize opportunities for the elucidation of common themes with respect to the host response and its
adverse consequences on the disease process. To this end, this application brings together as Project Leaders
four investigators who focus on diverse microbial pathogens from the point of view of both the pathogens
themselves and their impact on host inflammatory responses. To support these investigators, and to build a
pipeline of new investigators whose research is consistent with our underlying scientific theme, we propose to
provide an integrated and highly interactive faculty development plan for all Center investigators that leverages
the resources developed during Phase I to enable our Phase II Project Leaders and other Center investigators
to establish independently-funded research careers in an area consistent with this underlying theme (Aim 1); to
utilize the Administrative and Scientific Development (Core A) and Research and Technical Advancement
(Core B) cores developed during Phase I to continue to promote the scientific development of Center
investigators and enhance the overall research infrastructure on the host campuses (Aim 2); and to build on
the success of our Phase I efforts to recruit additional investigators whose research is consistent with the
underlying scientific theme and promote the development of collaborative, synergistic research relationships
among Center investigators (Aim 3). This will allow us to build on the success of Phase I Project Leaders to
establish a self-sustaining Center for Microbial Pathogenesis and Host Inflammatory Responses.

## Key facts

- **NIH application ID:** 10153387
- **Project number:** 3P20GM103625-09S1
- **Recipient organization:** UNIV OF ARKANSAS FOR MED SCIS
- **Principal Investigator:** MARK S SMELTZER
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $303,099
- **Award type:** 3
- **Project period:** 2012-08-15 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10153387

## Citation

> US National Institutes of Health, RePORTER application 10153387, Phenotypic and repertoire analysis of protective CD4 T cells induced by prime-boost vaccination against Chlamydia (3P20GM103625-09S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10153387. Licensed CC0.

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