# Core B - Genomics Core

> **NIH NIH U19** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $300,000

## Abstract

PROJECT SUMMARY 
The innate immune recognition of dengue virus infection triggers antiviral immune responses; however, there is 
little information about how the virus regulates these measures or how these responses affect dengue virus 
(DENV) disease pathogenesis and immunity. System biology approaches aimed at deciphering the complex 
interactions between DENV and host genes and pathways require accurate high-throughput measurements 
and comprehensive datasets and models. The purpose of this HIPC is to take advantage of recent advances in 
human immune profiling methods to characterize the early states of the human innate immune system 
following DENV infection and before and after vaccination against this infectious disease. The goal of the 
Genomics Core is to provide a central knowledge base and resource to define the human immune repertoire 
and develop predictors of disease and vaccine responses by using high throughput sequencing and 
bioinformatics that facilitate investigations of human immunity in well-characterized human cohorts. Other 
HIPC investigators will use this information to derive human immune profiles or signatures for disease in 
naturally acquired infection with known dengue immune status (Project 1), vaccine responsiveness and human 
challenge studies (Project 2), or DENV infection ex vivo with DENV strains of different virulence (Project 3). 
Network analysis of the human immune profiling data will identify pathways and genes for RNAi knockdown to 
determine how perturbations of the regulatory networks influence host responses during DENV infection. 
These studies are key to the overall goal of the HIPC to use high-throughput systems biology approaches to 
create molecular signatures that will define the human immune response profiles that correlate with the 
outcome of dengue virus infection or vaccination.

## Key facts

- **NIH application ID:** 10153658
- **Project number:** 5U19AI118610-07
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Steven M Wolinsky
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $300,000
- **Award type:** 5
- **Project period:** 2020-06-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10153658

## Citation

> US National Institutes of Health, RePORTER application 10153658, Core B - Genomics Core (5U19AI118610-07). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10153658. Licensed CC0.

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