# Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

> **NIH NIH U54** · CASE WESTERN RESERVE UNIVERSITY · 2021 · $1,290,333

## Abstract

RESEARCH CENTER SUMMARY
The overall objectives of this BETRNet Research Center (RC) are:
1) to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE)
and esophageal adenocarcinoma (EAC)
2) to increase the biological understanding of key observations made by our clinical researchers;
3) to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical
dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the
outcomes of EAC;
4) to foster a transdisciplinary and translational research culture and to effectively expand and enhance scientific
research focused on BE and EAC;
5) to evaluate research and transdisciplinary programs and to continuously improve research, productivity and
enhance translational implementation.
These objectives build and synergize on existing multi-institutional collaborative networks and the considerable
clinical, basic science, and translational expertise available at our institutions, focusing on improving the
outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to
focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that
influence the development of BE and EAC; and 2) to then translate laboratory discoveries into clinical
applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.

## Key facts

- **NIH application ID:** 10153699
- **Project number:** 5U54CA163060-10
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** AMITABH CHAK
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,290,333
- **Award type:** 5
- **Project period:** 2011-09-26 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10153699

## Citation

> US National Institutes of Health, RePORTER application 10153699, Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma (5U54CA163060-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10153699. Licensed CC0.

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