Core B (Metabolomics Component) - Project Summary The metabolomics core will support this Program Project application by providing infrastructure, expertise and support in metabolomics to investigators of the Program Project. The core will provide expertise in measurement of steady state levels of metabolites and their flux in cell lines and in tissue extracts isolated from a variety of genetically engineered mouse models. The metabolomics core will also provide assistance with downstream data analysis and interpretation in the context of pathways, as well as support the development and implementation of innovative methods to integrate OMICs-based datasets.