# Specialized pro-resolving mediators as potential medical countermeasures in a pig model of chlorine gas-induced acute lung injury

> **NIH NIH R21** · DUKE UNIVERSITY · 2021 · $241,500

## Abstract

Chlorine is a highly utilized chemical in the U.S. with more than 10 million metric tons produced
annually for purposes including water treatment, paper bleaching, and chemical manufacturing.
Unfortunately, however, chlorine is also a toxic inhalant. Exposure to chlorine gas can cause
immediate and sustained injury to the respiratory tract with the severity of injury depends on
both concentration and duration of exposure. Whereas exposure to chlorine gas is typically
accidental, it has been used as a chemical weapon since World War I. Despite its known
chemical threat potencies since World War I, there is no specific antidote for chlorine gas-induced injuries. Recent studies in our laboratory revealed that post-exposure treatment with specialized pro-resolving mediators (SPMs), such as Resolvin D1 and Protectin D1 strongly improved lung
injury outcomes in mice exposed to chlorine and hydrochloric acid (HCl). These SPMs are
endogenous lipid derivatives produced during inflammation cascade that subsequently
accelerates the resolution phase of inflammation. In the proposed grant application, we want to
test these novel potential therapeutic agents in our well-established pig model of chlorine gas-induced acute lung injury following the FDA's animal rule.

## Key facts

- **NIH application ID:** 10153787
- **Project number:** 5R21ES030331-02
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Satyanarayana Achanta
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $241,500
- **Award type:** 5
- **Project period:** 2020-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10153787

## Citation

> US National Institutes of Health, RePORTER application 10153787, Specialized pro-resolving mediators as potential medical countermeasures in a pig model of chlorine gas-induced acute lung injury (5R21ES030331-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10153787. Licensed CC0.

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