# PHYSIOLOGIC BIOMARKERS PREDICTING VENTILATORY INSTABILITY AND HYPOXEMIA IN PREMATURE INFANTS

> **NIH NIH U01** · WASHINGTON UNIVERSITY · 2020 · $205,052

## Abstract

PROJECT SUMMARY
The proposed study is a longitudinal cohort study of 100 to 110 preterm infants born
between 24 and 28 weeks gestation. It is designed to explore the contribution of
delayed or aberrant ventilatory control to the need for continued respiratory support at 8
to 12 weeks of age.. Infants will be categorized according to why they seem to need
respiratory support, using challenge studies. Ventilatory control will be further
investigated using novel techniques for calculation of loop gain of the respiratory system
and to explore the links between abnormalities seen by magnetic resonance imaging
(MRI) ands aberrant ventilatory control. The proposed studies are also designed to help
clarify the indications for airflow support, supplemental oxygen therapy and a ventilatory
stimulant – caffeine – as these infants grow and mature.

## Key facts

- **NIH application ID:** 10154013
- **Project number:** 3U01HL133700-05S1
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** JOHN L CARROLL
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $205,052
- **Award type:** 3
- **Project period:** 2016-09-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10154013

## Citation

> US National Institutes of Health, RePORTER application 10154013, PHYSIOLOGIC BIOMARKERS PREDICTING VENTILATORY INSTABILITY AND HYPOXEMIA IN PREMATURE INFANTS (3U01HL133700-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10154013. Licensed CC0.

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