# Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles

> **NIH NIH UM1** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $180,199

## Abstract

Project Summary/Abstract
Osteoarthritis (OA) is the single most important cause of disability in mid and late life. About 27 million
people in the United States suffer from this incurable process and 10 million have OA of the knee. Total knee
arthroplasty (TKA) is a reliable treatment option for patients disabled by knee OA who have failed nonoperative
treatment, with 58% of these surgeries being performed on patients 65 years or older. TKA surgeries were
performed on more than 700,000 patients in the United States in 2012 and estimates expect this number to
increase between 143% and 565% by 2050. Most patients experience pain relief within 6 to 12 weeks
following TKA; however, 8 to 34% of patients experience chronic postsurgical pain, defined by the International
Association for the Study of Pain as clinically important pain lasting more than 3 months after surgery, with
limited improvement in functional outcomes often despite an uneventful surgical course and a satisfactory
radiographic appearance. With one projected estimate of 3.48 million TKA surgeries per year in the USA by
2030, up to 500,000 patients annually could develop chronic pain following TKA. The objective of this project is
to aid in the construction of a dataset that encompasses clinical, biological (omics), psychological,
socioeconomical and imaging predictors for a diverse group of patients undergoing TKA. Rush University the
largest provider of joint replacement surgery in Illinois, performing 2,100 TKA procedures in 2017. With our
Institute for Translational Medicine (ITM) partners, the University of Chicago, and NorthShore University Health
System our NCATS CTSA-funded program hub has extensive translational research expertise and serves a
diverse patient population (>5 million) across many racial, ethnic and socioeconomic strata and collectively
perform more than 4000 TKA procedures per year. The overall project goal of the proposed research study is
to provide high fidelity clinical, biological and psychological data in conjunction with Clinical Coordination
Center, the Data Integration and Resource Center, and the Omics Data Generation Center from patients
undergoing TKA within our NCATS CTSA-funded program hub in line with NIH HEAL Initiative A2CPS. This
information should enrich our understanding of how acute pain becomes chronic pain following surgery and
enhance our ability to target effective preventive and treatment strategies for patients.

## Key facts

- **NIH application ID:** 10154121
- **Project number:** 3UM1NS112874-01S1
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** John W. Burns
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $180,199
- **Award type:** 3
- **Project period:** 2020-05-16 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10154121

## Citation

> US National Institutes of Health, RePORTER application 10154121, Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles (3UM1NS112874-01S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10154121. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*