# Implementing computerized substance use and depression screening and evidence-based treatments in an HIV primary care population

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $133,523

## Abstract

Abstract
 This proposed administrative supplement will take advantage of the extended study
follow-up to examine the relationship of changes in substance use over time to both mental
health outcomes and HIV clinical outcomes, and will also examine predictors of suicidal
ideation among people with HIV (PWH). Substance use disorders (SUDs) and depression are
common among PWH and lead to poor HIV treatment outcomes and increased mortality. To
enhance HIV care, the parent study examines the impact of self-administered computerized
screening for SUD risk and depression using validated measures. Screening is conducted every
six months, with results integrated into the electronic health record (EHR) and available for use
by the multidisciplinary HIV care team, including physicians and behavioral health specialists.
Screening uses validated measures (Tobacco, Alcohol, Prescription medication, and other
Substance use (TAPS); and Patient Health Questionnaire (PHQ-9) and Generalized Anxiety
Disorder (GAD-2) delivered via secure messaging and on tablets in waiting rooms. We extended
follow-up for clinic sites with a current total of 3,510 completed questionnaires to date,
including 2,291 online and 1,200 tablet completions. We anticipate completing a total of 3,600
completions, including 750 patients with multiple screenings, resulting in a robust longitudinal
dataset of SUD risk scores and mental health symptoms over time, which we will link to HIV
clinical outcomes (HIV viral control and CD4 cell counts) recorded in the electronic health
record. The proposed administrative supplement has three aims supporting analyses involving
the data from extended follow-up: 1) To evaluate clinical factors associated with longitudinal
changes in self-reported substance use and mental health symptoms. 2) To evaluate the
relationship of changes in drug and alcohol use over time with HIV clinical outcomes. 3) To
identify social, behavioral and clinical risk factors for suicidal ideation to inform ongoing care
for high-risk patients. Together, the objectives of the proposed supplement would enhance our
ability to address the specific aims of the original grant, by extending study findings to longer-
term substance use, mental health, and HIV outcomes and broaden the focus to include the
relationship of substance use and treatment to psychiatric symptoms including suicidal ideation.

## Key facts

- **NIH application ID:** 10155289
- **Project number:** 3R01DA043139-05S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Derek D Satre
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $133,523
- **Award type:** 3
- **Project period:** 2016-09-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10155289

## Citation

> US National Institutes of Health, RePORTER application 10155289, Implementing computerized substance use and depression screening and evidence-based treatments in an HIV primary care population (3R01DA043139-05S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10155289. Licensed CC0.

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