# Proteomics Core G

> **NIH NIH P30** · CASE WESTERN RESERVE UNIVERSITY · 2020 · $39,006

## Abstract

Project Summary Core G – Proteomics and Systems Biology 
 The Proteomics and Systems Biology Core G was created in 2010 in collaboration with the Case Center 
for Proteomics and Bioinformatics (CPB). The development of the Core was a direct response to increasing 
CFAR membership demand for proteomic services. The Core provides state-of-the-art proteomic 
instrumentation; computational resources and software for systems biology; proteomic methods development; 
consultation and training. Core G includes dedicated staff who are highly experienced in both structural and 
quantitative proteomics. Core G staff and CFAR faculty actively collaborate in grant proposals and development 
of novel technologies to advance CFAR members HIV related research. Over the past 5 years the faculty and 
staff from Core G have successfully partnered with CFAR scientists obtain $6.5 million in awards for HIV research 
where proteomics was an essential element. The project include the development novel assays, identification of 
biomarkers for HIV-induced chronic inflammation, and identification of targets for HIV infection and treatment. 
All these development projects are well aligned with the strategic foci of the CFAR working groups: 
Immunopathogenesis, Virology & Cure and Co-morbidities and Co-infections. 
 With the recent recruitment of Dr. Rafick Sékaly, who will become co-Director, the Core will be be able 
to dramatically expand the systems biology and bioinformatics tools available to HIV researchers. Dr. Mark 
Chance, Director, will continue to oversee the proteomics research. The Core plans to merge the sets of prioritary 
systems biology tools already available at CWRU with additional tools brought by Dr. Sékaly and his team. In 
addition there will be investment in the development of new software to address challenging problems in analysis 
of –omic scale data sets. Finally, Core G will work closely with the Virology, Next Generation Sequencing and 
Imaging Core, now co-Directed by Dr. Mark Cameron to analyze and compare large transcriptomic and 
proteomic data sets. The extensive data sets used to by Drs. Sekaly and Cameron to identify immune subset 
signatures and immune correlates of protection /pathogenesis panels will provide an invaluable resource for the 
CFAR's extensive programs on T-cell activation. Our specific aims are: 
 To provide advanced proteomic technologies to solve unmet needs in HIV research. 
 To develop and apply systems biology tools to solve unmet challenges in analysis of `-omic' data. 
 To provide consultation and training. 
In summary, the primary goal of Core G is to make advanced proteomic instrumentation and systems biology 
tools available to CFAR members for use in HIV research projects. The Core's skilled and highly approachable 
support staff assist investigators at every stage from experimental design to data analysis. Although Core G 
will continue to provide a drop-off service for routine analyses, its true strengt...

## Key facts

- **NIH application ID:** 10155683
- **Project number:** 3P30AI036219-25S1
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Mark James Cameron
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $39,006
- **Award type:** 3
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10155683

## Citation

> US National Institutes of Health, RePORTER application 10155683, Proteomics Core G (3P30AI036219-25S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10155683. Licensed CC0.

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