Abstract. The predoctoral Training Program in Biomolecular Pharmacology at Boston University launched in 1991 to meld quantitative principles of biomedical engineering (BME) with pharmacology & experimental therapeutics. It was honored in 1997 with an NIGMS T32 award. In the succeeding 23 years, this university-wide program has provided a supportive learning environment for predoctoral students. The Program includes an innovative curriculum, interdisciplinary laboratory rotations, industrial summer internships at Pfizer and Biogen, and diverse research training opportunities that span the campuses. Students enter via the Departments of Pharmacology, BME, or the university-wide Graduate Program for Neuroscience (GPN). Program trainees in BME and GPN experience an integrated curriculum, designed to provide enriched training in pharmacology coordinated with specialized training in their primary discipline. Trainees in Pharmacology gain access to diverse research and educational experiences that build upon those provided by pharmacology faculty. The core curriculum stresses fundamental pharmacological principles including interactions of bioactive molecules, drug delivery for novel therapeutics, animal models and relevance to the clinic, and challenges for modern drug discovery. The Program, recently enhanced with an NIGMS supplement on reproducibility in research, is structured to train students in the skills of rigorous scientific research, including study design, grant application, and publication. Participating faculty , originally 21 and now 47 contribute expertise in focus areas, including neuropharmacology, vascular and cancer pharmacology, genomics and proteomics, animal models (transgenic and behavioral), structural biology, nanotechnology, systems biology and medicinal chemistry. Career and professional development mentoring by faculty and student mentors, strengthened by BU’s NIH-funded career exploration program for Broadening Experiences in Scientific Training, provides steady opportunities relevant to their career and professional goals, whether in academia, government or the private sector. Training duration averages 5.3 years, and graduates compete well for positions in various sectors. The program provides stipend support for 5 trainees each year for appointment terms of 2 years. The missions, ethos and goals of the T32 program are to recruit the top tier of students who will be fully engaged with faculty mentors across the university, to enhance cross-disciplinary training in the biomedical sciences.