# Pediatric Paracorporeal and Extracorporeal Therapies (PPET) Summit 2021

> **NIH NIH R13** · BAYLOR COLLEGE OF MEDICINE · 2021 · $75,000

## Abstract

Project Summary
Pediatric paracorporeal and extracorporeal therapies (PPET) are increasingly applied to support
children with multiple organ failure (MOF). These highly complex, resource intensive technologies
lie at the interface of innovation and the highest complexity clinical care; in patients with MOF,
multiple treatment modalities are frequently used simultaneously. However, lack of clinical
guidelines or consensus statements to guide PPET use result in a lack of standardization of
practice, compounded by limited dialogue between experts and institutions regarding PPET use,
in particular in the application of multiple PPET modalities. Children are further disenfranchised
due to the lack of medical devices optimized for the varied size and physiological differences in
pediatric practice. There is a critical need for collaborative initiatives aimed at standardization of
practice, quality improvement, research and innovation as they relate to the applications of PPET.
The PPET Summit 2021 will transform these critical gaps into knowledge and research
opportunities by bringing together, for the first time, pediatric and adult experts from across the
globe in the fields of extracorporeal membrane oxygenation, ventricular assist device, renal
replacement therapy, extracorporeal liver support, and apheresis. The Summit will bring together
local and international experts to define the current status of PPET, including the role of hybrid
and tandem therapies; standardize current approaches; identify key knowledge gaps that need to
be addressed to facilitate optimal patient care, and set a collaborative research and quality
agenda to improve our understanding of PPET. This will provide an exciting and much needed
framework to optimize the care of these patients and improve their outcomes.
Preconference working groups, led by experts selected by the diverse organizing committee
around the core domains ((1) patient and family experiences and outcomes; (2) pharmacokinetics;
(3) standardization of terminology and quality metrics; (4) innovation; (5) ethics; (6) circuit and
organ interactions and cross-talk) will work in a series of highly structured virtual workshops to
maximize global participation in the months prior to the Summit to generate consensus
statements. The Summit itself will include state of-the-art presentations from the experts to define
the current status, underlining the importance of cross-pollination of multiple therapies and
approaches. On the final day, a session entitled `Map the Future' will bring together summaries
from the pre-conference workshops with all attendees to refine research imperatives for PPET
initiatives, including discussion of potential future summits. The proceedings of the first PPET
Summit will be disseminated as a series of leading articles in Critical Care and Resuscitation.

## Key facts

- **NIH application ID:** 10156359
- **Project number:** 1R13HD104433-01
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Ayse Akcan Arikan
- **Activity code:** R13 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $75,000
- **Award type:** 1
- **Project period:** 2020-12-07 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10156359

## Citation

> US National Institutes of Health, RePORTER application 10156359, Pediatric Paracorporeal and Extracorporeal Therapies (PPET) Summit 2021 (1R13HD104433-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10156359. Licensed CC0.

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