# A Precision high content screening assay for AB-mediated neuronal cell cycle reentry

> **NIH NIH R01** · UNIVERSITY OF VIRGINIA · 2020 · $161,500

## Abstract

Project Summary
We have established a human iPS-derived neuronal-glial cell model system that we are
using to (1) study AβO-induced neuronal cell cycle reentry (CCR) as well as (2) screen
for compounds that inhibit AβO-induced neuronal CCR. We now propose to adapt this
cell-based model system to evaluate the effects on SARS-CoV-2 spike protein-ACE2
binding on neuronal “fitness”, responsiveness and intracellular signaling as well as use to
screen for small molecule inhibitors that may used for the next generation SARS-CoV-2
therapeutics.

## Key facts

- **NIH application ID:** 10156953
- **Project number:** 3R01AG063400-02S1
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** ELIZABETH SHARLOW
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $161,500
- **Award type:** 3
- **Project period:** 2019-04-01 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10156953

## Citation

> US National Institutes of Health, RePORTER application 10156953, A Precision high content screening assay for AB-mediated neuronal cell cycle reentry (3R01AG063400-02S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10156953. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*