# A low-profile copper intrauterine device that delivers long-acting contraception an

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2020 · $748,698

## Abstract

ABSTRACT
The dual impacts of the HIV/AIDS pandemic and unintended pregnancies constitute a major health burden for
women worldwide and justify the development of highly-effective next-generation multipurpose prevention
technologies (NGM) that combine safe, effective, and easily reversible long-acting contraception with HIV
prevention. Here, we propose to adapt a memory wire copper intrauterine device (IUD) frame as a platform for
intrauterine delivery of antiretroviral (AVR) drugs to provide user friendly HIV pre-exposure prophylaxis (PrEP)
and contraception. We propose to evaluate ARV drug delivery systems compatible with IUD delivery for duel-
protection up to three years. In Aim 1, we will formulate candidate antiviral drug/prodrug solid dispersions in
matrix, reservoir and electrospun drug delivery systems and integrate these into an existing copper IUD to
optimize drug loading, dissolution rate, chemical and functional stability, and stable integration with and
functional attributes of the IUD. We will then evaluate the safety and pharmacokinetic effects of intrauterine
delivery of candidate devices in baboons, and measure drug concentrations in the vagina, cervix, and
endometrium. Finally, in Aim 3 we will use the macaque model to evaluate the protective efficacy of the drug-
eluting delivery system for HIV pre-exposure prophylaxis against a repeated low-dose vaginal SHIV162P3
challenge.

## Key facts

- **NIH application ID:** 10158876
- **Project number:** 1R01AI150325-01A1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** JEFFREY T. JENSEN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $748,698
- **Award type:** 1
- **Project period:** 2020-09-16 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10158876

## Citation

> US National Institutes of Health, RePORTER application 10158876, A low-profile copper intrauterine device that delivers long-acting contraception an (1R01AI150325-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10158876. Licensed CC0.

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