# Broadband X-ray Fluorescence Emission Tomography

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2021 · $535,245

## Abstract

Abstract
The goal of this proposed project is to develop an ultrahigh sensitivity, broadband X-ray fluorescence emission
tomography (XFET) system. This system combines advanced CdTe X-ray imaging spectrometers assembled
in a customized SPECT-like detection system design, and optimized source/filtering configurations to achieve
a dramatically improved sensitivity to a broad range of metal elements that emit fluorescence x-rays of 5-100
keV. This system would be ideally suited for imaging heavier elements, such as Hf, Gd, Au and Pt with
adequate tissue penetration for in vivo small animal studies.
As a design target, we seek to construct an XFET system that is capable of imaging these heavy metals at a
concentration of the order of 10 µg/ml in tissue equivalent, mouse-sized objects irradiated with X-ray sources
of ~10 mA tube current and up to 150 kVp, and with an imaging time of around 1-2 hours and at a spatial
resolution of a few hundred microns. This system would offer a unique imaging tool for guiding and monitoring
the delivery of radiation-induced and nanoparticle-mediated radiation therapy.

## Key facts

- **NIH application ID:** 10159267
- **Project number:** 5R01EB026300-04
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- **Principal Investigator:** Patrick Jean La Riviere
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $535,245
- **Award type:** 5
- **Project period:** 2018-08-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10159267

## Citation

> US National Institutes of Health, RePORTER application 10159267, Broadband X-ray Fluorescence Emission Tomography (5R01EB026300-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10159267. Licensed CC0.

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