# Interdisciplinary Training in Systems and Developmental Biology and Birth Defects

> **NIH NIH T32** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $190,115

## Abstract

ABSTRACT
Systems biology is a relatively new discipline used to understand the complex interactions underlying healthy
and diseased states of a cell, tissue, or organism, requiring knowledge of networks of processes and molecular
and protein interactions within and among cells, organs, and an organism as a whole. Studies of normal
development and birth defects are more established classical disciplines. The integration of systems biologic
approaches to the study of normal development and inborn errors of development is emerging. Scientists who
are versed in both mathematics and biology are needed to address the complexities of development biology by
examining the thousands to millions of factors and events that occur simultaneously in a temporospatial and
quantitative manner during the lifetime of an organism. Thus, to promote cross-training in these disciplines, we
are submitting a competitive renewal application to continue the integrated training program, “Interdisciplinary
Training in Systems and Developmental Biology and Birth Defects” at the Icahn School of Medicine at
Mount Sinai in New York City. During the past four years and one month, we successfully built a program that
includes 35 faculty members from 8 different departments, 4 institutes, and 4 multidisciplinary training areas
(Developmental and Regenerative Biology, Neurosciences, Genetics and Genomics Sciences, and Biophysics
and Systems Pharmacology) of the Graduate School of Biological Sciences at Mount Sinai. An outstanding
group of educators and scientists with expertise in systems biology, developmental biology or birth defects,
including the Directors and members of the External Advisory, Executive Faculty, and Curriculum Committees,
provide the leadership, administration, and mentorship for the program. The Curriculum emphasizes the
integration of concepts of developmental biology, inborn errors of development, genomics, molecular biology,
biochemistry, physiology, pharmacology, quantitative reasoning, computational biology, and bioinformatics. We
have created novel courses, journal clubs, and seminar series combining principles of systems biology,
developmental biology and birth defects in order to enhance the unique learning experience. The institutional
infrastructure for commitment and enhancement of diversity; selection of potential candidates; recruitment;
facilities and resources; training in responsible conduct of research and enhancing reproducibility; support for
career development; and training program evaluations are already existent for this training program. To date,
we have supported 13 PhD or MD/PhD candidates for 1 to 2 years on this training grant; 3 trainees have gone
on to receive their individual NIH F30 or 31 awards, and 3 trainees have graduated and are accepted into
excellent postdoctoral training programs. Our predoctoral program provides exciting and unique opportunities
for study from genomes and proteins to cells, animal models, and humans at the...

## Key facts

- **NIH application ID:** 10159749
- **Project number:** 5T32HD075735-09
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Ethylin Wang Jabs
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $190,115
- **Award type:** 5
- **Project period:** 2013-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10159749

## Citation

> US National Institutes of Health, RePORTER application 10159749, Interdisciplinary Training in Systems and Developmental Biology and Birth Defects (5T32HD075735-09). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10159749. Licensed CC0.

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