# ICH Recovery Grant

> **NIH NIH R01** · UNIVERSITY OF CINCINNATI · 2021 · $700,355

## Abstract

Project Summary/Abstract
 Stroke is the third leading cause of death and the leading cause of adult disability in the United States. More
adults are affected by stroke each year than Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis
or Parkinson’s disease. Hemorrhagic strokes represent the most severe subtypes of stroke. An estimated 40-
50% of hemorrhagic stroke victims will die and more than 80% of survivors remain disabled after hemorrhagic
stroke. Yet the vast majority of analyses on outcome after stroke have focused principally on gross measures
of functional outcome.
 Furthermore, hemorrhagic stroke differs from ischemic stroke where a loss of blood causes the area affected
to be readily visible on scanning. But with hemorrhagic stroke, not only the area that we can directly see, but
nearby tracts that have been compressed or stretched by the mass of the hemorrhage can be injured.
 We propose to follow-up on 500 cases of deep and lobar ICH to perform serial evaluations of motor and
cognitive function and advanced neuroimaging to determine predictors of recovery, progressive cognitive or
functional impairment. Our proposal has the advantages of adding onto a prospective ICH study which will
identify and recruit cases, ability to evaluate for the degree and impact of survival and severity biases, baseline
neuroimaging which includes baseline MRI, biologic samples including genotyping for apolipoprotein E alleles
and uniform phenotype definitions as well as expertise in recovery/outcome analyses, advanced neuroimaging
processes and epidemiologic study.

## Key facts

- **NIH application ID:** 10159984
- **Project number:** 5R01NS100417-05
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **Principal Investigator:** Daniel Woo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $700,355
- **Award type:** 5
- **Project period:** 2017-08-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10159984

## Citation

> US National Institutes of Health, RePORTER application 10159984, ICH Recovery Grant (5R01NS100417-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10159984. Licensed CC0.

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