COVID-19 has impacted all countries in the world. No populations remain untouched by either direct or indirect effects. Social distancing, isolation and a variety of challenges related to employment and access to basic needs are impacting every facet of everyday life. The impact of these COVID-19 restrictions and disease must be quantified to understand and mitigate short and long term effects across the cancer continuum, especially among the most vulnerable – underserved and minority populations and cancer patients. The goal of this study is to assess how differences in demographics (rural/urban, age, gender, race, educational attainment) will impact engagement in cancer preventive behaviors (e.g., tobacco cessation) and cancer management/survivorship behaviors (e.g., adherence to treatment, adherence to surveillance) in the context of COVID-19 environmental constraints (e.g., social distancing, employment, mental health, etc.) among adult healthy volunteers, cancer patients, and cancer survivors in Ohio, our catchment area.