The purpose of this 12-month study, “Impact of COVID-19 on cancer-related behaviors among nonmetropolitan and minorities in inland northern California: Seeking mitigation strategies” is to measure the impact of COVID-19 on cancer-related behaviors among 1,000 adult respondents and to explore whether telemedicine could be a mitigating factor. These respondents will intentionally over-represent non-metropolitan residents, African Americans, Native Americans, and populations who have Limited English Proficiency. Briefly, the aims are to [1] finalize IRB-approved instruments to measure the impact of COVID-19 on non-metropolitan and minority residents; [2] conduct data collection from these vulnerable populations in the UCDCCC catchment area; [3] disseminate findings to affected populations and to the NCI and professional audiences with the intent to apply insights to mitigation strategies. This Study will utilize qualitative data collection methods, e.g., mail, phone, FaceTime or its Android counterparts, and in-person to characterize responses from non-metropolitan residents, Native Americans, and populations who have limited English proficiency and qualitative research methods (key informant interviews and focus groups) to compile and develop responses from African Americans so that a patient-centered, telemedicine approach could be enhanced. These different methods reflect the premise that “one size does not fit all” and will facilitate the outreach strategies and opportunities in place. Successful achievements of these Aims will result in data that are not only aggregated for the full sample but also dis-aggregated by group (e.g., Native Americans) so that potential solutions might also be customized and shared with collaborators which include Feather River Tribal Health, Northern Valley Indian Health, bilingual/bicultural workers, and UC Davis Comprehensive Cancer Center.