# Diabetes Research Center

> **NIH NIH P30** · JOSLIN DIABETES CENTER · 2021 · $1,606,303

## Abstract

CENTER OVERVIEW – ABSTRACT
 For 30 years, the Diabetes Research Center (DRC) of the Joslin Diabetes Center, with its core
laboratories including the Boston University-Joslin Regional Computational core (BUJRC), Enrichment
Program, and Pilot and Feasibility (P&F) program, has synergized the collaborative expansion of basic and
clinical diabetes research at Joslin, Harvard Medical School (HMS) and the neighboring research institutions.
During the last 5 years, the Joslin Research Division generated paradigm-changing breakthroughs on the
understanding of the pathogenesis of various forms of diabetes and its complications. The success in making
these discoveries has been closely linked to the continuously evolving technologies and computational biology
services provided by the Joslin DRC. In addition, Joslin made significant renovations to many of its clinical and
research laboratories. This application summarizes the progress and innovations that have been made to the
various components of the Joslin DRC over this grant period. The Animal Physiology Core and Flow
Cytometry Core will have exciting new capabilities with the building of a germ-free mouse facility and the
acquisition of new cell sorting and imaging instruments. The Advanced Genomic and Genetics Core will
become the Molecular Phenotyping and Genotyping Core, allowing the incorporation of bioenergetics and new
DNA chip capabilities. The iPS Cell Core will be Genome Editing Core, introducing CRISPR-Cas9 technology
for cell-based and rodent model studies. The BUJRC Bioinformatics Core, due to significant increase in
demand, will be enlarged to add new services. The DRC is also proposing a new Clinical Translational
Research Center Core (CTRC), which will complement our renovated and enlarged Clinical Research Center
facility that is funded by Joslin. The CTRC is being proposed due to the significant increase in our translational
and clinical research studies, which now account for 50% of Joslin's research efforts. This new Core will
coordinate and synergize the large number of clinical/translational studies now on-going at Joslin and enhance
their capabilities by improving clinical design, specific procedures for metabolic studies, identification of special
diabetic populations and cohorts, and facilitating sources and resources for biological samples and
repositories.
 The previously DRC-supported Advanced Microscopy Core, the Animal Facilities, Specialized Assay
Core, Media Core and the Clinical Research Center will continue with support by Joslin. The P&F program has
been very successful in supporting early investigators, thus identifying innovative research at Joslin, Harvard
and Boston institutions. More than half of P+F Program awardees have subsequently competed successfully
for NIH support. The Enrichment Program is the largest diabetes and metabolic disease educational program
for post-doctoral fellows, students and investigators in the Harvard Medical School area, and is jointly
s...

## Key facts

- **NIH application ID:** 10160875
- **Project number:** 5P30DK036836-35
- **Recipient organization:** JOSLIN DIABETES CENTER
- **Principal Investigator:** GEORGE L KING
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,606,303
- **Award type:** 5
- **Project period:** 1997-02-15 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10160875

## Citation

> US National Institutes of Health, RePORTER application 10160875, Diabetes Research Center (5P30DK036836-35). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10160875. Licensed CC0.

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