# Animal Physiology Core

> **NIH NIH P30** · JOSLIN DIABETES CENTER · 2021 · $152,487

## Abstract

CORE 1 - ANIMAL PHYSIOLOGY CORE: ABSTRACT
The purpose of the Joslin Animal Physiology Core is to provide technically advanced physiological evaluation
of rodents for the study of diabetes, obesity, and their associated complications. The study of animal models is
an integral part of Joslin Research, and DRC investigators maintain more than 14,000 mice and rats in the
Joslin Animal Facility, and more than 8,000 mice offsite. Joslin DRC investigators have generated
approximately 170 strains of genetically engineered mice during the last 20 years, the majority of which have
been studied using the Animal Physiology Core.
Core services provided by the Animal Physiology Core include: Comprehensive Laboratory Monitoring
Systems (CLAMS) for the measurement of in vivo energy expenditure, activity and fuel utilization; Dual Energy
X-ray Absorptiometry (DEXA) for assessment of body composition; measurements of ECG, EEG, arterial blood
pressure, blood glucose levels, and core body temperature in mice and rats using telemetry systems; hypoxia
and hyperoxia using an OxyCycler; IVIS Spectrum CT for in vivo animal imaging; diurnal incubators for
controlled exposure to cold and thermoneutral temperatures; exercise using a rodent treadmill and activity
wheel cages; muscle strength of rodents in vivo using a grip strength meter.
As part of the Animal Physiology Core, Joslin will establish during the coming year a dedicated Germ-Free
Mouse Facility to study the role of the microbiome in metabolic diseases. Another critical role of the Animal
Physiology Core will be to continue to educate investigators and fellows on the theoretical understanding of
core procedures and data collection, to consult on study design, and to provide hands-on training for some
procedures and equipment.
The Animal Physiology Core has consistently provided services to DRC investigators (approximately 15/year)
and has been essential in the publication of multiple papers in high impact journals such as Nature, Cell
Metabolism, and the Journal of Clinical Investigation. Joslin support for the Animal Physiology Core has been
substantial with the purchase of many new pieces of equipment and maintenance of current equipment. During
the next year Joslin will fund physical development of the transitional Germ-Free Mouse Facility at a cost of
approximately $200,000. All of this support will continue to keep Joslin's animal-based research at the forefront
of diabetes research.

## Key facts

- **NIH application ID:** 10160877
- **Project number:** 5P30DK036836-35
- **Recipient organization:** JOSLIN DIABETES CENTER
- **Principal Investigator:** LAURIE J GOODYEAR
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $152,487
- **Award type:** 5
- **Project period:** 1997-02-15 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10160877

## Citation

> US National Institutes of Health, RePORTER application 10160877, Animal Physiology Core (5P30DK036836-35). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10160877. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*