# Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart Study

> **NIH NIH R01** · TULANE UNIVERSITY OF LOUISIANA · 2020 · $310,085

## Abstract

The parent study (R01AG062309) examines associations between lifespan
cardiometabolic exposures and midlife brain structure and function, as well as midlife
cognitive function, in the bi-racial, semi-rural Bogalusa Heart Study (BHS). The
importance of the main study is that it clarifies which cardiometabolic exposures
influence the brain health of a socioeconomically diverse group of African American and
white individuals at the portion of the lifespan (the 50s and early 60s) when cognitive
and brain health begins to become more heterogeneous and begins to include clinically-
significant cognitive decline in a large number of persons. This supplement adds three
additional cardiometabolic exposures to the set of exposures we will examine: sudden
reductions in physical activity, diet quality, and sleep quality caused by Covid-19 related
home confinement. BHS participants will receive the same set of diet, physical activity,
and sleep questionnaires that are assessed at each of their prior BHS study visits, along
with a new survey specifically designed to identify Covid19-related changes. There is an
extreme time urgency to assessing such confinement-related sudden lifestyle changes:
BHS participants are confined to the home now, and are therefore able to assess their
own confinement-related lifestyle changes now, rather than rely on error-prone recall of
distal events. The supplement significantly enhances the parent study by providing data
on exactly the sort of sudden, event-driven cardiometabolic changes that are important
to long-term outcomes, but are typically missed by a longitudinal cohort study such as
BHS, whose structure lends itself to measuring slowly-varying changes over the course
of years. The supplement could clarify the importance of such sudden lifestyle changes
to long-term health, relative to such slowly time-varying changes. In so doing, the
supplement could clarify the importance of rapidly deploying lifestyle interventions to
home-confined individuals to support high diet quality, physical activity attainment,
and sleep quality in the event of a future pandemic.

## Key facts

- **NIH application ID:** 10161514
- **Project number:** 3R01AG062309-02S1
- **Recipient organization:** TULANE UNIVERSITY OF LOUISIANA
- **Principal Investigator:** Lydia Bazzano
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $310,085
- **Award type:** 3
- **Project period:** 2019-02-15 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10161514

## Citation

> US National Institutes of Health, RePORTER application 10161514, Supplemental Funding Request for RF1 AG062309 Early life glycemic status and Alzheimer's disease neuroimaging markers in middle age: the Bogalusa Heart Study (3R01AG062309-02S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10161514. Licensed CC0.

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