# Neuroimaging Core

> **NIH NIH P30** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2021 · $371,008

## Abstract

Core F: NIC Summary/Abstract 
 The overall goal of the PITT-ADRC is to perform and promote research that increases our 
understanding of: 1) the etiology and pathogenesis of Alzheimer's disease (AD), 2) the mechanisms underlying 
the cognitive and behavioral symptoms of AD, and 3) to develop strategies that will result in effective early 
diagnoses and treatments for AD and related dementias. The Neuroimaging Core (NIC) will support these 
Center-wide goals by developing and applying cutting edge neuroimaging technology to studies that are 
focused on early and presymptomatic stages of the AD spectrum. 
 As the search for preclinical biomarkers continues, it is becoming increasingly clear that functional and 
structural brain imaging data may hold the key to identifying the earliest pathological manifestations of AD prior 
to any meaningful clinical change. The NIC will continue to develop and distribute technology for acquiring and 
interpreting brain functional and structural imaging data in the support of AD research. The NIC will advance 
the Center goals by supporting and promoting research that increases our understanding of the etiology and 
pathogenesis of AD and facilitates the development of new therapies and methods for monitoring therapeutic 
efficacy. The NIC maintains data sets of structural imaging on individuals enrolled through the Clinical Core, 
and we continue to work on the expansion of leading-edge analytic technologies, and novel radiotracer ligands 
measured with Positron Emission Tomography (PET) (i.e., PiB, AV-1451 and GTP-1). 
 The work of the NIC will accelerate efforts to identify early and presymptomatic AD by identifying 
imaging biomarkers to monitor the natural and treated history of the disease. The curated, “trial-ready” 
participant database will allow PITT-ADRC researchers to track biomarker-based clinical progression and to 
identify risk and protective factors. This database will also uniquely position the PITT-ADRC to identify potential 
participants based on specific biomarker characteristics. Finally, the NIC’s focus on quality assurance will 
ensure that neuroimaging methods are generating data measuring what they purport to measure and that the 
analysis stream retains the integrity of these data, ensuring that the statistical methodologies generate model 
that are biologically meaningful.

## Key facts

- **NIH application ID:** 10161691
- **Project number:** 5P30AG066468-02
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Ann D. Cohen
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $371,008
- **Award type:** 5
- **Project period:** 2020-05-15 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10161691

## Citation

> US National Institutes of Health, RePORTER application 10161691, Neuroimaging Core (5P30AG066468-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10161691. Licensed CC0.

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