# Genomic Resource Grant for the PhenX Toolkit - expansion and sustainability

> **NIH NIH U41** · RESEARCH TRIANGLE INSTITUTE · 2021 · $2,320,638

## Abstract

PROJECT SUMMARY/ABSTRACT 
The PhenX (consensus measures for Phenotypes and eXposures) Toolkit is a catalog of standard measures 
and associated bioinformatics tools that help investigators to improve the quality and consistency of their 
data collection and identify opportunities for collaborative research. Launchedin 2009, the PhenX Toolkit 
measures are being incorporated in several major studies and consortiums. This proposal describes our plan 
for the administration, management, and dissemination of the PhenX Toolkit over the next 5 years. Our 
overarching goals are to ensure that new tools and features to enrich the Toolkit user experience are 
completed efficiently and on time, to facilitate effective communication among the team and with 
stakeholders, to support the PhenX Steering Committee (SC), and to disseminate the Toolkit to the research 
community. Our management plan leverages our experience over the past 9 years and includes innovations 
to facilitate consensus and outreach to the larger community through the following specific aims. Overall 
Specific Aim 6: Project management and co-funded research: Enable effective communications and project 
management with a strong organization, assuring responsiveness, flexibility, and coordination of co-funding 
efforts. We will discuss the following subaims. Support the PhenX Research Teams (Section 3.3.2.1): The 
PhenX leadership team will develop and implement an administrative plan to guide team leaders, evaluate 
progress toward PhenX project goals and milestones, and assess the quality and utility of the PhenX Toolkit. 
Engage and Support the PhenX Steering Committee (Section 3.3.2.2): The PhenX SC provides overarching 
guidance to the project, including prioritizing and scoping domains to be addressed and providing guidance 
to Working Groups (WGs) during their deliberations. Together with the National Human Genome Research 
Institute (NHGRI) Project Scientist, the PhenX team will re-establish the SC and will provide organizational 
and logistical support for the in-person meetings and teleconferences. Disseminate the Toolkit to the 
Scientific Community (Section 3.3.2.3): The PhenX team will promote the PhenX Toolkit and engage the 
scientific community through publications in peer-reviewed journals, presentations, and exhibits at scientific 
conferences. Ensure Toolkit Accessibility (Section 3.3.2.4): In addition to providing the measures selected by 
the WGs to the research community, the PhenX Toolkit provides a variety of user-support features and 
information about the project. In the next phase, we propose to develop Application Programming Interfaces 
to promote communication and to implement responsive design to enable deployment on tablets and mobile 
devices. Coordinate Co-funded Research (Section 3.3.2.5): Ensure that co-funded projects are consistent 
with the overarching goals of PhenX and the guidance of the PhenX SC. In summary, our established 
leadership team will p...

## Key facts

- **NIH application ID:** 10161808
- **Project number:** 5U41HG007050-09
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** Carol Marie Hamilton
- **Activity code:** U41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,320,638
- **Award type:** 5
- **Project period:** 2013-07-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10161808

## Citation

> US National Institutes of Health, RePORTER application 10161808, Genomic Resource Grant for the PhenX Toolkit - expansion and sustainability (5U41HG007050-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10161808. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*
