# Genomic Resource Grant for PhenX Toolkit - expansion and sustainability: Resource Project

> **NIH NIH U41** · RESEARCH TRIANGLE INSTITUTE · 2021 · $235,827

## Abstract

PROJECT SUMMARY/ABSTRACT
The PhenX Toolkit is a catalog of standard measures and associated bioinformatics tools to help
investigators improve the quality and consistency of data collection and identify opportunities for
collaborative research. Launched in 2009, the PhenX Toolkit has expanded beyond genome-wide
association studies of common, complex diseases to include Rare Genetic Conditions, Substance Abuse
and Addiction, Mental Health, Sickle Cell Disease, and Tobacco Regulatory Research. PhenX measures
have become integral to other resources such as Research Electronic Data Capture (REDCap), the
database of Genotypes and Phenotypes (dbGaP), Logical Observation Identifiers Names and Codes
(LOINC), and the National Library of Medicine (NLM) Common Data Element (CDE) Resource Portal. PhenX
measures are being incorporated in several major studies and are being used in consortiums including the
Precision Medicine Initiative, which plans to enroll 1 million or more volunteers; the Adolescent Brain
Cognitive Development Study, which is the largest long-term study of brain development and child health
ever launched in the United States; and the Tobacco Centers of Regulatory Science. The proposed 5-year
research plan “Genomic Resource Grant for PhenX Toolkit – expansion and sustainability” focuses on
limited expansion of the Toolkit and on providing users with new tools for comparing measures and
connecting studies. We will continue collaborations that facilitate interactions between the Toolkit and
resources such as dbGaP, REDCap, and the NLM CDE Resource Portal and LOINC. We will also develop
educational modules and resources that will help existing users with the new tools and introduce the PhenX
Toolkit to the next generation of researchers. The PhenX multidisciplinary team will ensure that the PhenX
Toolkit continues to meet the needs of the scientific community through the following Specific Aims. Overall
Specific Aim 1: Expand PhenX Toolkit research domains: Address the evolving needs of Toolkit users and
the National Institutes of Health by adding PhenX measures related to cancer, environmental exposures,
pediatrics, and mental health. Overall Specific Aim 2: Maintain and extend existing collaborations: Raise
awareness of complementary efforts and facilitate navigation between the Toolkit and resources such as
dbGaP, REDCap, the NLM CDE Resource Portal, and LOINC. Overall Specific Aim 3: Raise awareness and
increase impact: Toolkit users and the studies they lead will benefit from increased uptake of PhenX
measures. We propose a multifaceted educational component to raise awareness and increase use of
PhenX measures and tools. In summary, we will increase the breadth and depth of the Toolkit to support the
evolving needs of the scientific community, extend successful collaborations to further integrate PhenX with
existing resources, and take advantage of educational environments to promote use and introduce the next
generation of scientists to...

## Key facts

- **NIH application ID:** 10161810
- **Project number:** 5U41HG007050-09
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** Carol Marie Hamilton
- **Activity code:** U41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $235,827
- **Award type:** 5
- **Project period:** 2013-07-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10161810

## Citation

> US National Institutes of Health, RePORTER application 10161810, Genomic Resource Grant for PhenX Toolkit - expansion and sustainability: Resource Project (5U41HG007050-09). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10161810. Licensed CC0.

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