# Computational Analysis Core

> **NIH NIH U54** · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2021 · $264,181

## Abstract

Core 2 – Project Summary
The Computational Analysis Core (Core 2) will support Projects 1 & 2 by bringing necessary bioinformatics
and computational methods to bear on the questions addressed by each project. More specifically, we will
apply established computational pipelines to perform quality control on, and extract maximal information (cell
types, states, circuits, and drivers) from, our rich data sets. We will help our CSBC team identify the cell types,
states, and circuits active in the Leukemia and Colon and Pancreatic tumor models of Core 1 from the single-
cell RNA-Seq data collected in Projects 1 & 2, as well as the molecular drivers of interesting behaviors. We
will deploy numerical algorithms to uncover the predictive power of phenotypic measurements, alone or in
combination, made via our Nanowell (NW) and Suspended Microchannel Resonator (SMR) platforms to
explain cancer cell drug responses. When necessary, we will identify and/or develop new algorithms,
enhancing our CSBC's quantitative and multivariate capabilities. Finally, we will work closely with our CSBC
team members to help with experimental design, ensuring that an appropriate number of cells/samples are
processed to test hypotheses of interest and that appropriate statistical testing is performed. By providing
comprehensive analysis (QC, power, gene set enrichment) and modeling capabilities, we will
dramatically enhance our ability to draw crucial insights from our data. This will lead to new
hypotheses that can be tested by designing new experiments.

## Key facts

- **NIH application ID:** 10162306
- **Project number:** 5U54CA217377-05
- **Recipient organization:** MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** DOUGLAS A LAUFFENBURGER
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $264,181
- **Award type:** 5
- **Project period:** 2017-06-07 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10162306

## Citation

> US National Institutes of Health, RePORTER application 10162306, Computational Analysis Core (5U54CA217377-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10162306. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*