# Hydrogen Sulfide Regulation in Cardioprotection

> **NIH NIH R01** · BROWN UNIVERSITY · 2021 · $576,009

## Abstract

Project Summary
 Hydrogen sulfide (H2S) is an important signaling molecule with potent cytoprotective
actions in cardiovascular systems. Current results indicate that modulation of H2S levels
could have potential therapeutic value for a number of disease states such as vasodilation,
anti-inflammation, and anti-oxidation. However, the exact mechanisms of action are still
unclear and the actual H2S concentration/flux needed to exhibit the optimal protection in
those disease models are to be determined. This lack of knowledge presents a major burden
in the development of H2S based therapy. To solve this problem, research tools that can
effectively detect H2S and specifically supply/remove H2S in biological samples are needed.
In this application we plan to develop highly sensitive fluorescent probes for H2S detection.
We will also develop novel H2S releasing agents and scavenging agents. The new
chemicals will be used to determine the optimal H2S profiles for cardioprotection in models of
myocardial ischemia/reperfusion (MI/R) injury and heart failure. This study will establish
useful protocols guiding the development of H2S therapy.

## Key facts

- **NIH application ID:** 10162413
- **Project number:** 5R01HL151398-02
- **Recipient organization:** BROWN UNIVERSITY
- **Principal Investigator:** DAVID JOSEPH LEFER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $576,009
- **Award type:** 5
- **Project period:** 2020-05-11 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10162413

## Citation

> US National Institutes of Health, RePORTER application 10162413, Hydrogen Sulfide Regulation in Cardioprotection (5R01HL151398-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10162413. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*