# Genomics

> **NIH NIH P30** · UNIVERSITY OF CHICAGO · 2021 · $295,917

## Abstract

ABSTRACT
The University of Chicago Medicine Comprehensive Cancer Center (UCCCC) Genomics Core Facility (GCF) is
tasked with providing state-of-the-art genomics data generation services to University of Chicago faculty in a
fee-for-service model. UCCCC members’ fees are subsidized by the Cancer Center Support Grant (CCSG) via
a co-pay mechanism. At present, the GCF main services are next-generation sequencing, DNA microarray
analysis, and Sanger sequencing. The GCF also provides data storage services to its clients and partners with
the Bioinformatics Core Facility (BiCF) for genomic data analysis. The GCF is organized into two Subcores,
Next-Generation Sequencing and Microarrays Subcore, and DNA Sequencing and Genotyping Subcore, and
has been located on the first floor of the Knapp Center for Biomedical Discovery (KCBD) since 2009. The GCF
is directed scientifically by Yoav Gilad, PhD, Professor of Human Genetics, and operationally by Pieter Faber,
PhD, with the assistance of William Buikema, PhD, as Technical Director of the DNA Sequencing and
Genotyping Subcore. In addition to the leadership, the GCF employs nine technologists (six in the Next-
Generation Sequencing and Microarrays Subcore, and three in the DNA Sequencing and Genotyping
Subcore). Core developments in the current funding period include increased emphasis on next-generation
sequencing (NGS) services to meet demand and advancements in the field. The main operating instruments of
the Facility include Applied Biosystems 3730xl DNA analyzers (DNA Sequencing and Genotyping Subcore), an
Illumina HiScan, and an Affymetrix GeneScan3000 microarray scan system, as well as three Illumina next-
generation sequencing instruments (HiSEQ4000, HiSEQ2500, and a NextSeq500; Next-Generation
Sequencing and Microarrays Subcore). The GCF effectively serves users’ needs, and the services provided
using these instruments occupy 80-90% of the available instrument and/or personnel time, indicating that
staffing and instrumentation are operating and maintained at an appropriate level. UCCCC members receive
priority, and projects are prioritized based on sample reception date and project urgency. To direct operations,
Drs. Gilad and Faber meet on a biweekly basis, discussing any operational issues, as well as short-term and
long-term strategies. Additionally, Drs. Gilad and Faber meet regularly with the GCF Faculty Oversight
Committee (FOC) to receive constructive feedback from expert users in the genomics field. To best serve
users’ needs and gauge user satisfaction, the University of Chicago Office of Shared Research Facilities under
the leadership of George Langan, DVM, conducts annual on-campus user surveys. The most recent survey
from August 2016 showed a high approval rating (approximately 80%), with 99% of responders predicting
continued use of the Facility in the future. New services will be added as needed (e.g., the Facility intends to
add single cell RNA-SEQ to its repertoire (DROP-SEQ protocol) ...

## Key facts

- **NIH application ID:** 10162513
- **Project number:** 5P30CA014599-46
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Yoav Gilad
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $295,917
- **Award type:** 5
- **Project period:** 1997-09-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10162513

## Citation

> US National Institutes of Health, RePORTER application 10162513, Genomics (5P30CA014599-46). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10162513. Licensed CC0.

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